Drug Analysis Quizzes for Pharmaceutics Students

Question 1

In quantitative drug analysis, which technique relies on the Beer-Lambert law to determine drug concentrations in solutions?

Accepted Answer

Spectrophotometry

Answer

Gas chromatography (GC)

Answer

High-performance liquid chromatography (HPLC)

Answer

Mass spectrometry (MS)

Question 2

Which of the following analytical techniques is primarily employed for the identification of drug impurities?

Accepted Answer

Gas chromatography coupled with mass spectrometry (GC-MS)

Answer

UV-Vis spectrophotometry

Answer

Fourier transform infrared (FTIR) spectroscopy

Answer

High-performance liquid chromatography (HPLC)

Question 3

What is the fundamental principle underlying UV-Vis spectrophotometry in drug analysis?

Accepted Answer

Measurement of light absorption by drug molecules at specific wavelengths

Answer

Separation of drug molecules based on their size and charge

Answer

Identification of drug molecules based on their mass-to-charge ratios

Answer

Quantification of drug molecules based on their electrochemical properties

Question 4

What is the primary role of internal standards in drug quantification by HPLC?

Accepted Answer

To compensate for variations in sample preparation and injection volume

Answer

To identify unknown drug impurities

Answer

To enhance the sensitivity of the analytical method

Answer

To separate drug molecules based on their polarity

Question 5

What is the main objective of conducting a forced degradation study on a drug product?

Accepted Answer

To identify potential degradation pathways and products under exaggerated conditions

Answer

To determine the stability of the drug product under extreme environmental conditions

Answer

To develop accelerated aging protocols for drug storage

Answer

To evaluate the impact of manufacturing processes on drug stability

Question 6

When developing an analytical method for trace impurity analysis, which consideration is of paramount importance?

Accepted Answer

Achieving high sensitivity and selectivity to detect trace impurities

Answer

Minimizing sample preparation steps to reduce analysis time

Answer

Ensuring fast analysis times to increase throughput

Answer

Keeping instrumentation costs low

Question 7

Which type of drug degradation product is formed when drugs are exposed to acidic or basic conditions?

Accepted Answer

Hydrolytic products

Answer

Oxidative products

Answer

Photolytic products

Question 8

Which official document sets quality standards and analytical procedures for drugs used in the United Kingdom?

Accepted Answer

British Pharmacopoeia (BP)

Answer

United States Pharmacopoeia (USP)

Answer

European Pharmacopoeia (EP)

Answer

International Pharmacopoeia (IP)

Question 9

Which analytical technique is primarily employed for qualitative drug identification?

Accepted Answer

Ultraviolet-visible spectrophotometry (UV-Vis)

Answer

Atomic absorption spectrometry

Answer

Gas chromatography coupled with mass spectrometry (GC-MS)

Answer

High-performance liquid chromatography (HPLC)

Question 10

A pharmaceutical company seeks to determine the purity of an active pharmaceutical ingredient (API) in a finished product. Which analytical method is most suitable for this purpose?

Accepted Answer

Liquid chromatography coupled with mass spectrometry (LC-MS)

Answer

Karl Fischer titration

Answer

Polarography

Answer

X-ray diffraction

Question 11

What is the primary objective of a system suitability test in HPLC?

Accepted Answer

To verify that the HPLC system meets specified performance criteria

Answer

To calibrate the HPLC system for a specific analyte

Answer

To identify impurities present in the sample

Answer

To determine the concentration of the analyte in the sample

Question 12

What is the role of an internal standard in quantitative HPLC analysis?

Accepted Answer

To account for variations in sample preparation and injection

Answer

To calibrate the HPLC system for the analyte

Answer

To identify impurities present in the sample

Answer

To enhance the peak shape of the analyte

Question 13

Which is NOT a type of impurity that can be found in drugs?

Accepted Answer

Excipients

Answer

Structural impurities

Answer

Process-related impurities

Answer

Degradation products

Question 14

Which sample preparation technique separates analytes based on their solubility differences in two non-mixable solvents?

Accepted Answer

Liquid-liquid extraction

Answer

Solid-phase extraction

Answer

Supercritical fluid extraction

Answer

Gas chromatography

Question 15

In UV-Vis spectrophotometry, what underlies drug molecule analysis?

Accepted Answer

Absorption of ultraviolet and visible light

Answer

Fluorescence emission

Answer

Electrochemical reactions

Answer

Mass-to-charge ratio measurements

Question 16

What is the primary purpose of validation in drug analysis?

Accepted Answer

Ensuring analytical method accuracy and reliability

Answer

Determining drug product shelf life

Answer

Assessing drug substance stability

Answer

Comparing different analytical methods

Question 17

What is the British Pharmacopoeia's (BP) role in drug analysis?

Accepted Answer

Establishing official standards and analytical methods

Answer

Regulating drug manufacturing and distribution

Answer

Evaluating drug safety and efficacy

Answer

Conducting research on new drug therapies

Question 18

What is the fundamental principle of capillary electrophoresis in drug analysis?

Accepted Answer

Size and charge-based separation of charged molecules

Answer

Stationary phase-based separation of molecules

Answer

Volatility-based separation of molecules

Answer

Solubility-based separation of molecules

Question 19

Which step is NOT part of the core drug analysis process?

Accepted Answer

Excipient characterization

Answer

Sample preparation

Answer

Drug identification

Answer

Impurities profiling

Question 20

Which chromatographic technique is specifically designed for the separation of enantiomers, which are chiral drugs?

Accepted Answer

Enantioselective chromatography

Answer

Supercritical fluid chromatography

Answer

Gas chromatography

Answer

Affinity chromatography

Question 21

Mass spectrometry (MS) separates ions based on which parameter?

Accepted Answer

Mass-to-charge ratio

Answer

Size

Answer

Charge

Answer

Solubility

Question 22

Which sample preparation method involves extracting a drug from a solid matrix using a liquid solvent?

Accepted Answer

Solid-liquid extraction

Answer

Supercritical fluid extraction

Answer

Liquid-liquid extraction

Answer

Microwave-assisted extraction

Question 23

What is the primary purpose of using internal standards in drug analysis?

Accepted Answer

To account for variations in analytical conditions and compensate for losses during sample preparation and analysis

Answer

To increase the sensitivity of the assay

Answer

To identify unknown impurities

Answer

To validate the analytical method

Question 24

Validation of an analytical method ensures:

Accepted Answer

Accuracy, precision, and reliability of the method

Answer

Identification of drug impurities

Answer

Cost-effectiveness of the analysis

Answer

Compliance with regulatory guidelines

Question 25

When developing an analytical method for drug analysis, which factors are of utmost importance?

Accepted Answer

Sensitivity, specificity, accuracy, and precision

Answer

Regulatory compliance

Answer

Simplicity and ease of operation

Answer

Cost and speed of analysis

Question 26

Distinguish between qualitative and quantitative analytical methods in drug analysis.

Accepted Answer

Qualitative methods detect the presence of a substance, while quantitative methods measure its concentration

Answer

Both qualitative and quantitative methods require extensive sample preparation

Answer

Qualitative methods are more accurate than quantitative methods

Answer

Quantitative methods can also identify unknown substances