Pharmacokinetic Parameters: Online Quizzes and Learning Resources

Question 1

The area under the curve (AUC) is commonly used to calculate drug clearance.

Accepted Answer

True

Answer

False

Question 2

The volume of distribution can be expressed in units of liters or milliliters per kilogram.

Accepted Answer

True

Answer

False

Question 3

A limitation of using the area under the curve (AUC) to calculate clearance is that it assumes a linear relationship between drug concentration and time.

Accepted Answer

True

Answer

False

Question 4

Factors that can increase the volume of distribution include high lipid solubility, low protein binding, and a large molecular size.

Accepted Answer

True

Answer

False

Question 5

Clearance is a measure of the rate of drug elimination from the body.

Accepted Answer

True

Answer

False

Question 6

How does an increased volume of distribution affect drug elimination?

Accepted Answer

Slower drug elimination

Answer

Faster drug elimination

Answer

No impact on drug elimination

Answer

Only affects drug distribution, not elimination

Question 7

Which of the following accurately calculates the volume of distribution (Vd)?

Accepted Answer

Vd = AUC / Dose

Answer

Vd = Dose / AUC

Answer

Vd = Clearance / Elimination rate constant

Answer

Vd = Elimination rate constant / Clearance

Question 8

A drug has a half-life of 8 hours. What percentage of its original concentration remains in the body after 24 hours?

Accepted Answer

12.5%

Answer

25%

Answer

50%

Answer

75%

Question 9

Which graphical representation is commonly used to determine drug clearance?

Accepted Answer

Ln(concentration)-time plot

Answer

AUC-time plot

Answer

Concentration-time plot

Answer

Linear regression plot

Question 10

A drug characterized by high clearance and low Vd will exhibit:

Accepted Answer

Short half-life and low plasma concentration

Answer

Long half-life and high plasma concentration

Answer

Short half-life and high plasma concentration

Answer

Long half-life and low plasma concentration

Question 11

Which pharmacokinetic parameter represents the theoretical volume of body fluid in which a drug appears to be distributed?

Accepted Answer

Volume of distribution

Answer

Clearance

Answer

Half-life

Answer

Area under the curve (AUC)

Question 12

Which of the following methods is NOT used to estimate clearance?

Accepted Answer

Vd and AUC

Answer

Apparent volume of distribution (Vd) and elimination rate constant (k)

Answer

Dose and plasma concentration

Answer

Area under the curve (AUC) and elimination rate constant (k)

Question 13

A drug has a Vd of 5 liters and a clearance of 10 mL/min. Calculate its elimination half-life:

Accepted Answer

5 hours

Answer

0.5 hours

Answer

50 hours

Answer

500 hours

Question 14

Steady-state concentration of a drug is achieved when:

Accepted Answer

The rate of drug elimination equals the rate of drug administration

Answer

The drug concentration in plasma is constant

Answer

The peak and trough concentrations are equal

Answer

Vd is equal to AUC

Question 15

A drug with a large Vd is more likely to:

Accepted Answer

Have a long half-life

Answer

Be highly protein bound

Answer

Be rapidly eliminated

Answer

Have a narrow therapeutic index

Question 16

Which of the following can be used to determine the bioavailability of a drug?

Accepted Answer

AUC

Answer

Cmax

Answer

tmax

Answer

Vd

Question 17

The pharmacokinetic parameter that represents the amount of drug in the body per unit volume of distribution is:

Accepted Answer

Volume of distribution

Answer

Half-life

Answer

Area under the curve

Answer

Clearance

Question 18

If the clearance of a drug is 10 mL/min and the drug concentration in plasma is 100 ng/mL, the rate of drug elimination is:

Accepted Answer

1000 ng/min

Answer

100 ng/min

Answer

10 ng/min

Answer

10000 ng/min

Question 19

The area under the curve (AUC) represents:

Accepted Answer

Total drug exposure

Answer

Time to reach peak concentration

Answer

Peak drug concentration

Answer

Rate of drug absorption

Question 20

If the volume of distribution of a drug is 10 L and the initial drug concentration is 100 mg/L, the total amount of drug in the body is:

Accepted Answer

1000 mg

Answer

100 mg

Answer

10 mg

Answer

1 mg

Question 21

The pharmacokinetic parameter that is independent of drug dose is:

Accepted Answer

Half-life

Answer

Volume of distribution

Answer

Area under the curve

Answer

Clearance

Question 22

If the clearance of a drug is 50 mL/min and the volume of distribution is 10 L, the elimination rate constant is:

Accepted Answer

0.005 min^-1

Answer

0.5 min^-1

Answer

5 min^-1

Answer

0.05 min^-1

Question 23

If the half-life of a drug is 2 hours, it will take approximately how long for the drug concentration to decrease by 90%?

Accepted Answer

6 hours

Answer

3 hours

Answer

9 hours

Answer

12 hours