Antiviral Drugs: Master the Basics for Pharmacy Students

Question 1

Acyclovir's mechanism of action involves:

Accepted Answer

Blocking the binding of the viral DNA polymerase to its substrate.

Answer

Inhibiting viral uncoating.

Answer

Interfering with viral attachment to host cells.

Answer

Suppressing viral RNA replication.

Question 2

Amantadine is indicated for the treatment of:

Accepted Answer

Influenza A virus infections

Answer

Herpes simplex virus infections

Answer

Cytomegalovirus infections

Answer

Hepatitis B virus infections

Question 3

A common adverse effect associated with oseltamivir is:

Accepted Answer

Nausea

Answer

Liver damage

Answer

Bone marrow suppression

Answer

Neurological toxicity

Question 4

Which class of antiviral drugs targets the viral envelope?

Accepted Answer

Envelope fusion inhibitors

Answer

Nucleoside analogs

Answer

Protease inhibitors

Answer

Non-nucleoside reverse transcriptase inhibitors

Question 5

Which of the following is NOT a route of transmission for viral infections?

Accepted Answer

Ingestion of contaminated food or water

Answer

Direct contact with infected individuals

Answer

Contact with contaminated surfaces

Answer

Inhalation of respiratory droplets

Question 6

Which of the following mechanisms of action is NOT a target for antiviral drugs?

Accepted Answer

Promoting viral latency

Answer

Inhibiting viral attachment and entry

Answer

Interfering with viral replication

Answer

Blocking viral assembly and release

Question 7

What is the primary target of oseltamivir?

Accepted Answer

Viral neuraminidase

Answer

Viral hemagglutinin

Answer

Viral RNA polymerase

Answer

Viral protease

Question 8

Which of the following antiviral drugs is indicated for the treatment of hepatitis C virus (HCV) infection?

Accepted Answer

Sofosbuvir

Answer

Tenofovir

Answer

Enfuvirtide

Answer

Emtricitabine

Question 9

Which of the following antiviral drugs is categorized as a protease inhibitor?

Accepted Answer

Ritonavir

Answer

Acyclovir

Answer

Oseltamivir

Answer

Ribavirin

Question 10

Which of the following is the primary mechanism of action of nucleoside analogues in antiviral therapy?

Accepted Answer

Inhibit viral DNA synthesis by acting as fraudulent building blocks

Answer

Inhibit viral RNA synthesis by blocking the viral RNA polymerase

Answer

Inhibit viral protein synthesis by binding to the viral ribosome

Answer

Inhibit viral entry by interfering with viral attachment to host cells

Question 11

What is the primary target of protease inhibitors in the treatment of HIV infection?

Accepted Answer

Viral protease

Answer

Viral RNA polymerase

Answer

Viral reverse transcriptase

Answer

Viral integrase

Question 12

What is the mechanism of action of neuraminidase inhibitors in antiviral therapy?

Accepted Answer

Inhibit viral release from infected cells

Answer

Inhibit viral attachment to host cells

Answer

Inhibit viral RNA replication

Answer

Inhibit viral DNA synthesis

Question 13

Which of the following is a primary indication for the use of valacyclovir?

Accepted Answer

Treatment of herpes zoster

Answer

Prevention of cytomegalovirus disease in transplant recipients

Answer

Treatment of HIV

Answer

Treatment of hepatitis C

Question 14

Which of the following is NOT a potential mechanism of action for antiviral drugs?

Accepted Answer

Enhancement of viral entry

Answer

Targeting viral capsid proteins

Answer

Induction of host immune responses

Answer

Inhibition of viral replication

Question 15

Which class of antiviral drugs is commonly used to treat infections caused by herpesviruses, including herpes simplex virus?

Accepted Answer

Nucleoside analogues

Answer

Integrase inhibitors

Answer

Neuraminidase inhibitors

Answer

Protease inhibitors

Question 16

Which of the following statements about oseltamivir is accurate?

Accepted Answer

It is a neuraminidase inhibitor that is most effective when initiated within 48 hours of influenza symptom onset.

Answer

It is a nucleoside analogue that targets viral DNA polymerase.

Answer

It is used to treat HIV infections.

Answer

It does not require metabolic activation to become active in the body.

Question 17

Which type of antiviral drug targets and interferes with the synthesis of viral DNA or RNA?

Accepted Answer

Nucleoside analogue

Answer

Protease inhibitor

Answer

Integrase inhibitor

Answer

Neuraminidase inhibitor

Question 18

Which of the following statements about the use of antiviral drugs for influenza is true?

Accepted Answer

They can reduce the severity and duration of symptoms, but they are not effective in preventing infection.

Answer

They are equally effective against all strains of influenza virus.

Answer

They can be used to treat influenza in patients of all ages.

Answer

They have no significant adverse effects.

Question 19

Which of the following is a potential benefit of using combination antiviral therapy?

Accepted Answer

Reduced risk of viral resistance and improved clinical outcomes

Answer

Lower cost of treatment

Answer

Fewer potential adverse effects

Answer

Convenience of taking multiple medications

Question 20

Acyclovir exerts its antiviral effect by:

Accepted Answer

Inhibiting viral DNA polymerase

Answer

Inhibiting viral RNA polymerase

Answer

Cleaving viral RNA

Answer

Blocking viral entry into host cells

Question 21

Oseltamivir is clinically indicated for all of the following EXCEPT:

Accepted Answer

Treating active cytomegalovirus infection

Answer

Preventing influenza infection in high-risk individuals

Answer

Preventing influenza infection

Answer

Treating severe influenza infection

Question 22

Which of the following represents a common target for antiviral drug action?

Accepted Answer

Viral enzymes essential for replication

Answer

Host cell mitochondria

Answer

Host cell ribosomes

Answer

Host cell DNA

Question 23

A common mechanism of antiviral drug resistance is:

Accepted Answer

Mutation of the target enzyme

Answer

Increased drug metabolism by the liver

Answer

Increased excretion of the drug by the kidneys

Answer

Enhanced host immune response against the virus

Question 24

Which of the following drugs is classified as a nucleoside analog antiviral?

Accepted Answer

Zidovudine

Answer

Nevirapine

Answer

Oseltamivir

Answer

Ritonavir

Question 25

Which drug exemplifies a non-nucleoside reverse transcriptase inhibitor (NNRTI)?

Accepted Answer

Nevirapine

Answer

Zidovudine

Answer

Lamivudine

Answer

Acyclovir

Question 26

Which of the following is a protease inhibitor commonly employed in HIV treatment regimens?

Accepted Answer

Ritonavir

Answer

Enfuvirtide

Answer

Acyclovir

Answer

Oseltamivir