Cholinergic Drugs: Interactive Learning Quizzes for Master of Pharmacy Students

Question 1

Which of the following is not a recognized muscarinic receptor subtype?

Accepted Answer

M6

Answer

M1

Answer

M2

Answer

M3

Question 2

Pilocarpine exerts its pharmacological effects primarily as a:

Accepted Answer

Muscarinic receptor agonist

Answer

Muscarinic receptor antagonist

Answer

Nicotinic receptor agonist

Answer

Nicotinic receptor antagonist

Question 3

Which of the following accurately describes the mechanism of action of nicotine?

Accepted Answer

Activation of nicotinic receptors

Answer

Inhibition of acetylcholinesterase

Answer

Blockade of muscarinic receptors

Answer

Stimulation of dopamine release

Question 4

Which of the following is a competitive antagonist of muscarinic receptors?

Accepted Answer

Atropine

Answer

Acetylcholine

Answer

Pilocarpine

Answer

Nicotine

Question 5

Which of the following drugs belongs to the class of synthetic tertiary amine compounds?

Accepted Answer

Bethanechol

Answer

Acetylcholine

Answer

Choline

Answer

Pilocarpine

Question 6

What is the unique mode of action of botulinum toxin?

Accepted Answer

Prevention of neurotransmitter release from presynaptic terminals

Answer

Inhibition of acetylcholinesterase enzyme

Answer

Activation of muscarinic receptors

Answer

Blockade of nicotinic receptors

Question 7

Cholinergic drugs are used in the management of several conditions. Which of the following conditions is generally NOT treated with cholinergic drugs?

Accepted Answer

Hyperthyroidism

Answer

Myasthenia gravis

Answer

Glaucoma

Answer

Alzheimer's disease

Question 8

Identify the primary site of action of muscarinic cholinoreceptor agonists.

Accepted Answer

Smooth muscle

Answer

Skeletal muscle

Answer

Central nervous system

Answer

Cardiac muscle

Question 9

Which cholinergic drug is commonly used in the management of Alzheimer's disease?

Accepted Answer

Tacrine

Answer

Neostigmine

Answer

Propantheline

Answer

Atropine

Question 10

Describe the primary mechanism of action of nicotinic cholinoreceptor antagonists.

Accepted Answer

Blockage of acetylcholine receptors

Answer

Stimulation of acetylcholine release

Answer

Potentiation of acetylcholine effects

Answer

Inhibition of acetylcholinesterase

Question 11

Identify the drug of choice for reversing the neuromuscular blockade caused by non-depolarizing muscle relaxants.

Accepted Answer

Neostigmine

Answer

Atropine

Answer

Propantheline

Answer

Physostigmine

Question 12

Identify the drug that is a selective M3 muscarinic cholinoreceptor antagonist.

Accepted Answer

Pirenzepine

Answer

Tiotropium

Answer

Trihexyphenidyl

Answer

Scopolamine

Question 13

What is the primary mechanism of action of nicotinic agonists?

Accepted Answer

Binding to and gating ion channels

Answer

Inhibition of acetylcholinesterase

Answer

Stimulation of muscarinic receptors

Answer

Activation of phospholipase C

Question 14

Which of the following factors does NOT affect the binding of cholinergic drugs to their receptors?

Accepted Answer

Ion concentration

Answer

Drug concentration

Answer

Receptor affinity

Answer

Receptor occupancy

Question 15

Which of the following is a characteristic of nicotinic acetylcholine receptors?

Accepted Answer

Ligand-gated ion channels

Answer

G protein-coupled receptors

Answer

Enzymatic proteins

Answer

Nuclear hormone receptors

Question 16

Which of the following is NOT a potential therapeutic use of muscarinic antagonists?

Accepted Answer

Parkinson's disease

Answer

Asthma

Answer

Overactive bladder

Answer

Motion sickness

Question 17

Which receptor subtype do nicotinic agonists bind to?

Accepted Answer

Nicotinic receptor

Answer

Muscarinic receptor

Answer

Adrenergic receptor

Answer

Dopamine receptor

Question 18

Which of the following is NOT a mechanism of action of muscarinic agonists?

Accepted Answer

Inhibition of acetylcholine release

Answer

Activation of phospholipase C

Answer

Increase in intracellular calcium concentration

Answer

Contraction of smooth muscle

Question 19

Which of the following drugs is a selective muscarinic M3 receptor antagonist?

Accepted Answer

Tiotropium

Answer

Pilocarpine

Answer

Methacholine

Answer

Neostigmine

Question 20

Which of the following is a clinical use of nicotinic agonists?

Accepted Answer

Myasthenia gravis

Answer

Glaucoma

Answer

Asthma

Answer

Parkinson's disease

Question 21

Which of the following is a side effect of anticholinergic drugs?

Accepted Answer

Dry mouth

Answer

Miosis

Answer

Bronchitis

Answer

Bradycardia

Question 22

Which of the following drugs is a depolarizing neuromuscular blocking agent?

Accepted Answer

Suxamethonium

Answer

Vecuronium

Answer

Neostigmine

Answer

Atropine

Question 23

Which of the following is a mechanism of action of cholinesterase inhibitors?

Accepted Answer

Reversible inhibition of acetylcholinesterase

Answer

Activation of muscarinic receptors

Answer

Stimulation of dopamine release

Answer

Blockade of nicotinic receptors

Question 24

Which of the following is a clinical use of cholinesterase inhibitors?

Accepted Answer

Alzheimer's disease

Answer

Parkinson's disease

Answer

Huntington's disease

Answer

Multiple sclerosis

Question 25

Which of the following is a contraindication to the use of anticholinergic drugs?

Accepted Answer

Glaucoma

Answer

Hypertension

Answer

Diabetes

Answer

Asthma