B Cell Biology Quizzes: Test Your Understanding

Question 1

Which type of B cell is responsible for producing antibodies in response to an encountered antigen?

Accepted Answer

Plasma cell

Answer

Naive B cell

Answer

Memory B cell

Answer

Immature B cell

Question 2

What is the primary function of the B cell receptor (BCR)?

Accepted Answer

Binding to specific antigens

Answer

Transmitting signals for B cell activation

Answer

Producing antibodies

Answer

Activating T cells

Question 3

Which cytokine is crucial for promoting B cell activation, proliferation, and differentiation?

Accepted Answer

Interleukin-4 (IL-4)

Answer

Interleukin-2 (IL-2)

Answer

Interferon-gamma (IFN-γ)

Answer

Tumor necrosis factor (TNF)

Question 4

What is the term for the process by which B cells undergo genetic recombination to generate diverse antibody repertoires?

Accepted Answer

V(D)J recombination

Answer

Class switching

Answer

Affinity maturation

Answer

Somatic hypermutation

Question 5

What is the name of the cell population that presents processed antigens to B cells, initiating their activation?

Accepted Answer

Dendritic cells

Answer

Macrophages

Answer

Neutrophils

Answer

Natural killer cells

Question 6

Which of the following receptors is **specifically** expressed on the surface of mature B cells?

Accepted Answer

BCR

Answer

TCR

Answer

FcR

Answer

MHC-II

Question 7

Which class of antibodies typically has the **highest** affinity for an antigen?

Accepted Answer

IgG

Answer

IgM

Answer

IgA

Answer

IgD

Question 8

What is the **primary** function of IgM antibodies?

Accepted Answer

Complement activation

Answer

Neutralization

Answer

Opsonization

Answer

Blocking receptor binding

Question 9

What is the primary role of germinal centers in B cell biology?

Accepted Answer

Selection of high-affinity antibodies

Answer

Generation of memory B cells

Answer

Production of plasma cells

Answer

Activation of naive B cells

Question 10

Which of the following cytokines is crucial for B cell differentiation into plasma cells?

Accepted Answer

IL-4

Answer

IL-2

Answer

IL-10

Answer

IFN-gamma

Question 11

What is the mechanism by which B cells undergo class switch recombination?

Accepted Answer

Deletion and reassembly of DNA segments at switch regions

Answer

DNA polymerase-mediated base pair exchange

Answer

RNA-editing of existing immunoglobulin genes

Answer

Translocation of immunoglobulin heavy chain genes

Question 12

Which of the following is a major surface molecule expressed on activated B cells?

Accepted Answer

CD40

Answer

CD19

Answer

CD23

Answer

CD80

Question 13

What is the main function of memory B cells?

Accepted Answer

Differentiate into plasma cells upon antigen reactivation

Answer

Produce antibodies immediately upon antigen exposure

Answer

Present antigens to T cells

Answer

Act as regulatory B cells

Question 14

Which type of antibody response is primarily mediated by B-1 cells?

Accepted Answer

T-cell independent

Answer

Th1-type

Answer

Th2-type

Answer

IgM-mediated

Question 15

What is a key role of dendritic cells in B cell biology?

Accepted Answer

Activation and presentation of antigens to B cells

Answer

Induction of B cell tolerance

Answer

Production of antibodies

Answer

Suppression of T cell responses

Question 16

Which of the following is NOT a stage in B cell development?

Accepted Answer

Plasma cell

Answer

Pre-B cell

Answer

Pro-B cell

Answer

Immature B cell

Question 17

What is the primary function of germinal centers?

Accepted Answer

To generate high-affinity antibodies through somatic hypermutation and class switch recombination.

Answer

To produce memory B cells.

Answer

To activate T cells.

Question 18

Which of the following cytokines is a key regulator of B cell activation and class switch recombination?

Accepted Answer

IL-4

Answer

TNF-α

Answer

IFN-γ

Answer

IL-10

Question 19

What is the primary role of CD40 in B cell biology?

Accepted Answer

To promote B cell proliferation, differentiation, and survival through interaction with its ligand, CD40L.

Answer

To bind to the B cell receptor.

Answer

To inhibit B cell activation.

Question 20

What is the mechanism by which B cells generate antibodies with high affinity for their target?

Accepted Answer

Somatic hypermutation and affinity maturation.

Answer

Class switch recombination

Answer

Cytokine signaling

Answer

Epigenetic regulation

Question 21

Which of the following is a characteristic of memory B cells?

Accepted Answer

Long-lived, rapidly activated upon re-exposure to antigen, and capable of producing high-affinity antibodies.

Answer

Produce IgM antibodies

Answer

Express high levels of MHC II

Question 22

What is the role of follicular dendritic cells in B cell biology?

Accepted Answer

To capture and present antigen to B cells, promoting their differentiation into memory B cells and antibody-producing plasma cells.

Answer

To activate T cells.

Question 23

Which of the following disorders is characterized by a severe deficiency in B cells and impaired antibody production?

Accepted Answer

X-linked agammaglobulinemia

Answer

Chronic lymphocytic leukemia

Answer

Multiple myeloma

Question 24

What is the primary mechanism by which antibodies protect against infection?

Accepted Answer

By binding to pathogens, neutralizing their infectivity, and facilitating their elimination through phagocytosis.

Answer

By inducing phagocytosis

Answer

By activating complement

Answer

By releasing cytokines