Principles of Neuropharmacology: Master the Mechanisms of Drug Action on the Nervous System

Question 1

Which factor does NOT affect the distribution of a drug in the body?

Accepted Answer

Patient's age

Answer

Lipid solubility

Answer

Protein binding

Question 2

Which of the following does **not** influence drug-receptor interactions?

Accepted Answer

Drug metabolism

Answer

Receptor affinity

Answer

Receptor density

Answer

Receptor desensitization

Question 3

In the treatment of Parkinson's disease, which drug is primarily employed?

Accepted Answer

Levodopa

Answer

Propranolol

Answer

Fluoxetine

Answer

Seizure

Question 4

Which neurotransmitter is the primary inhibitory neurotransmitter in the central nervous system, responsible for decreasing neuronal excitability?

Accepted Answer

GABA

Answer

Dopamine

Answer

Glutamate

Answer

Serotonin

Question 5

Which of the following describes a key feature of the interaction between a drug and its receptor?

Accepted Answer

Stereospecificity

Answer

Irreversibility

Answer

Covalent binding

Answer

Ionic bonding

Question 6

Identify the drug that acts as a competitive antagonist at its receptor:

Accepted Answer

Propranolol

Answer

Morphine

Answer

Epinephrine

Answer

Acetylcholine

Question 7

The therapeutic index of a drug is a measure of:

Accepted Answer

Both its effectiveness and safety

Answer

Its effectiveness

Answer

Its safety

Answer

Its potency

Question 8

Which of the following is a common adverse effect associated with opioid analgesics?

Accepted Answer

Respiratory depression

Answer

Hypertension

Answer

Tachycardia

Answer

Mydriasis

Question 9

Which neurotransmitter system plays a primary role in regulating mood?

Accepted Answer

Serotonergic

Answer

Dopaminergic

Answer

GABAergic

Answer

Glutamatergic

Question 10

The blood-brain barrier significantly impacts drug distribution in the central nervous system.

Accepted Answer

True

Answer

False

Question 11

Which of the following drugs, a benzodiazepine, is commonly used to treat anxiety disorders?

Accepted Answer

Diazepam

Answer

Fluoxetine

Answer

Lithium

Answer

Lamotrigine

Question 12

Which of the following is NOT a mechanism of drug action on the nervous system?

Accepted Answer

Altering gene expression

Answer

Binding to receptors

Answer

Modulating ion channels

Answer

Inhibiting enzymes

Question 13

A drug that binds to a receptor and prevents its activation is known as a(n):

Accepted Answer

Antagonist

Answer

Agonist

Answer

Partial agonist

Answer

Inverse agonist

Question 14

The primary neurotransmitter responsible for activating the sympathetic nervous system is:

Accepted Answer

Norepinephrine

Answer

Dopamine

Answer

Serotonin

Answer

Acetylcholine

Question 15

Which of the following drugs is used in the treatment of Parkinson's disease?

Accepted Answer

Levodopa

Answer

Donepezil

Answer

Fluoxetine

Answer

Diazepam

Question 16

The blood-brain barrier serves to:

Accepted Answer

Regulate the movement of substances into and out of the brain

Answer

Protect the brain from harmful substances

Answer

Control blood flow to the brain

Answer

Produce cerebrospinal fluid

Question 17

The therapeutic index of a drug refers to:

Accepted Answer

The ratio of the toxic dose to the minimum effective dose

Answer

The difference between the peak and trough plasma concentrations

Answer

The time period during which the drug is effective

Question 18

Which of the following neurotransmitters is involved in the regulation of mood and sleep?

Accepted Answer

Serotonin

Answer

GABA

Answer

Dopamine

Answer

Glutamate

Question 19

Which of the following is an adverse effect commonly associated with antipsychotics?

Accepted Answer

Extrapyramidal symptoms

Answer

Bronchodilation

Answer

Hypertension

Answer

Bradycardia

Question 20

Which of the following is a muscarinic cholinoreceptor agonist?

Accepted Answer

Pilocarpine

Answer

Atropine

Answer

Salbutamol

Answer

Propranolol

Question 21

Which of the following is a glutamatergic drug?

Accepted Answer

NMDA receptor antagonists

Answer

Amphetamines

Answer

Opioids

Question 22

Which of the following is an indication for the use of dopamine agonists?

Accepted Answer

Parkinson's disease

Answer

Depression

Answer

Epilepsy

Answer

Schizophrenia