Gastrointestinal Pathology Quizzes: Test Your Knowledge of Digestive System Pathology

Question 1

Which of the following is a key pathological feature of peptic ulcer disease?

Accepted Answer

Erosion of the mucosal lining

Answer

Mucosal inflammation

Answer

Hyperplasia of gastric glands

Answer

Increased acid secretion

Question 2

Identify the characteristic histological finding in chronic gastritis.

Accepted Answer

Lymphocytic infiltration of the gastric mucosa

Answer

Hypertrophy of parietal cells

Answer

Erosion of the mucosal lining

Answer

Neutrophilic abscess formation

Question 3

Identify the primary cause of cirrhosis.

Accepted Answer

Chronic inflammation

Answer

Ischemia

Answer

Neoplasia

Answer

Congenital disorders

Question 4

Identify the primary function of Kupffer cells within the liver.

Accepted Answer

Phagocytosis

Answer

Bile production

Answer

Lipid metabolism

Answer

Detoxification

Question 5

Which of the following is the primary cause of peptic ulcer disease?

Accepted Answer

Helicobacter pylori infection

Answer

Non-steroidal anti-inflammatory drug (NSAID) use

Answer

Stress

Answer

Alcohol consumption

Question 6

Which of the following is NOT a characteristic feature of Crohn's disease?

Accepted Answer

Ulcerative colitis

Answer

Transmural inflammation

Answer

Skip lesions

Answer

Cobblestone appearance on colonoscopy

Question 7

The primary causative agent of peptic ulcer disease is:

Accepted Answer

Helicobacter pylori infection

Answer

Excessive alcohol consumption

Answer

Nonsteroidal anti-inflammatory drug (NSAID) use

Answer

Smoking

Question 8

The most common cause of acute viral hepatitis is:

Accepted Answer

Hepatitis A virus (HAV)

Answer

Hepatitis B virus (HBV)

Answer

Hepatitis C virus (HCV)

Answer

Epstein-Barr virus (EBV)

Question 9

The characteristic histological feature of Crohn's disease is:

Accepted Answer

Formation of granulomas

Answer

Presence of crypt abscesses

Answer

Microscopic colitis

Answer

Abundance of lymphoid aggregates

Question 10

The predominant histological type of pancreatic cancer is:

Accepted Answer

Adenocarcinoma

Answer

Squamous cell carcinoma

Answer

Neuroendocrine tumor

Answer

Lymphoma

Question 11

A characteristic feature of celiac disease is:

Accepted Answer

Villous atrophy

Answer

Crypt hyperplasia

Answer

Eosinophilic infiltration

Answer

Increased goblet cell count

Question 12

In the context of liver disease, which statement about liver enzyme testing is most accurate?

Accepted Answer

Tracking changes in liver enzyme levels provides more valuable information than a single measurement.

Answer

Elevated liver enzymes invariably indicate extensive liver damage.

Answer

Liver enzyme tests are exclusively used for diagnosing liver disease.

Question 13

Identify the key mechanisms underlying hepatocellular injury and their significance in the progression of liver disease.

Accepted Answer

Hepatocyte apoptosis, inflammation, and hepatic stellate cell activation are crucial in liver injury and fibrosis.

Answer

Liver injury arises solely from direct toxic insults, without any inflammatory involvement.

Answer

Liver fibrosis can be completely reversed, regardless of the extent or duration of the underlying injury.

Answer

Hepatocellular regeneration has a minimal impact on liver disease progression.

Question 14

Which of the following is a characteristic morphological feature of a peptic ulcer?

Accepted Answer

Deep excavation with overhanging edges

Answer

Superficial mucosal erosion

Answer

Neoplastic thickening of the submucosa

Answer

Epithelial atrophy and hypoplasia

Question 15

In the pathogenesis of inflammatory bowel disease (IBD), which immune cell type plays a central role?

Accepted Answer

T-helper cells

Answer

B-lymphocytes

Answer

Neutrophils

Answer

Macrophages

Question 16

Which liver disease is characterized by the accumulation of numerous large lipid droplets within hepatocytes?

Accepted Answer

Non-alcoholic fatty liver disease (NAFLD)

Answer

Viral hepatitis

Answer

Autoimmune hepatitis

Answer

Alcoholic liver disease

Question 17

Which histological pattern is typically seen in primary sclerosing cholangitis (PSC)?

Accepted Answer

Concentric periductal fibrosis

Answer

Biliary stasis with inspissated bile

Answer

Bridging fibrosis

Answer

Portal-based fibrosis

Question 18

Which of the following is a potential complication of celiac disease?

Accepted Answer

Malabsorption syndrome

Answer

Perforation

Answer

Cholelithiasis

Answer

Hepatic encephalopathy

Question 19

Which of the following is a histopathological feature of Helicobacter pylori infection?

Accepted Answer

Neutrophilic antral gastritis

Answer

Eosinophilic esophagitis

Answer

Giant cell hepatitis

Answer

Lymphoid aggregates in the colon

Question 20

What is the characteristic histological feature of hepatocellular carcinoma?

Accepted Answer

Trabecular architecture with irregular cords of tumor cells

Answer

Acinar arrangement with uniform glandular structures

Answer

Dysplastic tubules with irregular epithelial lining

Question 21

What is the most common cause of acute pancreatitis?

Accepted Answer

Gallstones

Answer

Alcoholism

Answer

Trauma

Answer

Viral infection

Question 22

What is the hallmark histological feature of Helicobacter pylori infection?

Accepted Answer

Gastritis with prominent neutrophilic infiltration

Answer

Dysplasia of the gastric epithelium

Answer

Intestinal metaplasia in the stomach lining

Answer

Adenocarcinoma of the stomach