Biopharmaceutics: Drug Absorption and Bioavailability Quizzes

Question 1

Which of the following factors does NOT influence the extent of drug absorption?

Accepted Answer

Patient's age

Answer

Route of administration

Answer

Solubility of the drug in the gastrointestinal tract

Answer

Presence of food in the stomach

Question 2

Bioavailability refers to:

Accepted Answer

The fraction of an administered dose that reaches systemic circulation unchanged

Answer

The rate at which a drug is absorbed

Answer

The maximum concentration of a drug in the body

Answer

The time it takes for a drug to reach its peak concentration

Question 3

Which of the following methods is used to establish bioequivalence between two drug products?

Accepted Answer

Pharmacokinetic studies in healthy volunteers

Answer

In vitro dissolution testing

Answer

Clinical trials in patients

Answer

Animal studies

Question 4

The purpose of an in vitro-in vivo correlation (IVIVC) is to:

Accepted Answer

Predict the bioavailability of a drug based on its in vitro dissolution profile

Answer

Determine the pharmacokinetic parameters of a drug

Answer

Assess the stability of a drug product

Answer

Identify potential drug interactions

Question 5

Which of the following steps is typically the rate-limiting factor in drug absorption?

Accepted Answer

Dissolution

Answer

Diffusion through the gastrointestinal tract

Answer

Metabolism

Answer

Excretion

Question 6

The half-life of a drug is defined as the time required for the body to:

Accepted Answer

Eliminate half of the drug

Answer

Absorb half of the drug

Answer

Metabolize half of the drug

Answer

Distribute half of the drug

Question 7

The area under the curve (AUC) is a pharmacokinetic parameter that reflects:

Accepted Answer

The total amount of drug absorbed

Answer

The maximum concentration of drug in the body

Answer

The time it takes for the drug to reach its peak concentration

Answer

The rate of drug elimination

Question 8

Which of the following is NOT a factor that influences drug absorption?

Accepted Answer

Distribution of the drug in the body

Answer

Physicochemical properties of the drug

Answer

Route of administration

Answer

Patient's age

Question 9

What is the primary purpose of a bioequivalence study?

Accepted Answer

To determine if two drug products are therapeutically equivalent

Answer

To evaluate the bioavailability of a new drug product

Answer

To establish the pharmacokinetic profile of a drug

Answer

To assess the safety and efficacy of a new drug

Question 10

Which of the following is NOT a method used to establish an in vitro-in vivo correlation (IVIVC)?

Accepted Answer

Clinical trials

Answer

Dissolution testing

Answer

Permeability studies

Answer

Computer modeling

Question 11

What is the primary significance of the Henderson-Hasselbalch equation in biopharmaceutics?

Accepted Answer

It predicts the fraction of ionized drug at a given pH

Answer

It determines the solubility of a drug in different solvents

Answer

It calculates the volume of distribution of a drug

Answer

It estimates the clearance of a drug

Question 12

What is the main role of surfactants in drug absorption?

Accepted Answer

They increase the solubility of drugs in water

Answer

They decrease the permeability of biological membranes

Answer

They inhibit the efflux of drugs from cells

Answer

They enhance the stability of drugs

Question 13

What is a key advantage of using a prodrug in biopharmaceutics?

Accepted Answer

Improved drug absorption

Answer

Increased drug stability

Answer

Reduced drug toxicity

Answer

Enhanced drug targeting

Question 14

According to the biopharmaceutical classification system (BCS), which class of drugs has the highest solubility and permeability?

Accepted Answer

Class I

Answer

Class II

Answer

Class III

Answer

Class IV

Question 15

How does pH typically affect the absorption of weak acids and bases?

Accepted Answer

Weak acids are better absorbed in acidic pH, while weak bases are better absorbed in basic pH

Answer

Weak acids are better absorbed in basic pH, while weak bases are better absorbed in acidic pH

Answer

pH does not significantly affect the absorption of weak acids or bases

Answer

Weak acids and bases are equally absorbed at all pH levels

Question 16

Bioavailability refers to:

Accepted Answer

The fraction of drug that reaches systemic circulation unchanged

Answer

The rate at which a drug is absorbed

Answer

The maximum concentration of a drug in the blood

Answer

The time it takes for a drug to reach its peak concentration

Question 17

Which of the following is a purpose of conducting bioequivalence studies?

Accepted Answer

To compare the bioavailability of different drug products

Answer

To determine the optimal dosage regimen

Answer

To evaluate the safety and efficacy of a new drug

Answer

To investigate drug-drug interactions

Question 18

Which of the following is a limitation of dissolution testing?

Accepted Answer

It is not predictive of in vivo drug absorption

Answer

It does not account for drug solubility

Answer

It requires a large volume of dissolution medium

Answer

It is time-consuming

Question 19

The first-pass effect refers to:

Accepted Answer

The metabolism of a drug before it reaches systemic circulation

Answer

The distribution of a drug to various tissues

Answer

The excretion of a drug via the kidneys

Answer

The accumulation of a drug in the liver

Question 20

Which of the following is NOT a recognized factor influencing drug absorption?

Accepted Answer

Age

Answer

Blood flow to the absorption site

Answer

Route of administration

Answer

Physicochemical properties of the drug

Question 21

What term describes the fraction of an administered drug that reaches the systemic circulation in an unchanged form?

Accepted Answer

Bioavailability

Answer

Pharmacokinetic profile

Answer

In vitro-in vivo correlation

Answer

Bioequivalence

Question 22

Which of the following is a commonly employed method for evaluating bioequivalence of two drug products?

Accepted Answer

Comparison of AUC and Cmax values

Answer

Solubility testing

Answer

Dissolution profiling

Answer

In vitro disintegration testing

Question 23

What is the primary objective of establishing an in vitro-in vivo correlation?

Accepted Answer

To predict the in vivo performance of a drug based on in vitro data

Answer

To determine the solubility of a drug

Answer

To assess the bioavailability of a drug

Question 24

Differentiate between first-pass metabolism and enterohepatic circulation.

Accepted Answer

First-pass metabolism occurs in the liver, while enterohepatic circulation involves the repeated cycling of drugs between the liver and intestine

Answer

First-pass metabolism is more significant for oral drugs, while enterohepatic circulation is more important for intravenous drugs

Question 25

Which of the following parameters is NOT used to characterize the dissolution profile of a drug product?

Accepted Answer

Disintegration time

Answer

Dissolution efficiency

Answer

Mean dissolution time

Answer

Time to 50% release

Question 26

How does particle size influence drug absorption?

Accepted Answer

Smaller particles generally exhibit faster and more extensive absorption

Answer

Particle size has no significant impact on drug absorption

Answer

Smaller particles exhibit slower and less extensive absorption