Solid Dosage Forms: Master the Basics for Pharmacists

Question 1

Why is it crucial to evaluate disintegration time for solid dosage forms? How does this parameter influence drug release and bioavailability?

Accepted Answer

Rapid disintegration enables swift drug release, boosting bioavailability.

Answer

Extended disintegration sustains drug release, prolonging therapeutic effects.

Answer

Disintegration time is irrelevant for oral solid dosage forms.

Answer

Disintegration time applies solely to capsules, not tablets.

Question 2

Which manufacturing technique is unique to tablets, distinguishing them from capsules?

Accepted Answer

Compression

Answer

Filling preformed shells

Answer

Coating

Answer

Encapsulation of excipients

Question 3

Identify the most commonly used excipient as a binder in tablet formulations?

Accepted Answer

Starch

Answer

Magnesium stearate

Answer

Talc

Answer

Sodium Lauryl Sulphate

Question 4

Which quality control test specifically evaluates the resistance of tablets to breaking or chipping?

Accepted Answer

Friability test

Answer

Hardness test

Answer

Disintegration test

Answer

Dissolution test

Question 5

What is the primary purpose of a capsule designed for controlled drug release?

Accepted Answer

Sustained drug release over an extended period

Answer

Enhanced drug absorption

Answer

Reduced drug side effects

Answer

Improved drug stability

Question 6

In a powder formulation, what is the specific function of a suspending agent?

Accepted Answer

Maintain drug particles in suspension

Answer

Enhance drug solubility

Answer

Improve powder flowability

Answer

Prevent caking

Question 7

Which of the following is **not** a type of solid dosage form?

Accepted Answer

Suppositories

Answer

Tablets

Answer

Capsules

Answer

Powders

Question 8

The primary function of a capsule shell is to:

Accepted Answer

Facilitate swallowing

Answer

Mask the taste of the drug

Answer

Protect the drug from moisture

Answer

Prolong the release of the drug

Question 9

How do the solubility and particle size of an active pharmaceutical ingredient (API) affect the disintegration time, dissolution rate, and bioavailability of a tablet dosage form?

Accepted Answer

Increased API solubility leads to faster disintegration and dissolution, enhancing bioavailability.

Accepted Answer

Larger API particles result in slower disintegration and dissolution, potentially hindering bioavailability.

Answer

API particle size has no significant impact on tablet disintegration or drug absorption.

Answer

Increased API solubility negatively impacts disintegration time and positively impacts dissolution rate.

Question 10

Which of the following factors has the LEAST impact on the absorption and bioavailability of solid dosage forms taken orally?

Accepted Answer

Skin color

Answer

Formulation

Answer

Particle size

Answer

Gastric pH

Question 11

Which of the following is NOT classified as a solid dosage form?

Accepted Answer

Ointment

Answer

Tablet

Answer

Capsule

Question 12

Which factor is most crucial in determining the ease of manufacturing and quality of tablets during the compression process?

Accepted Answer

Particle size and distribution

Answer

Drug polymorphism

Answer

API moisture content

Answer

Tablet shape

Question 13

Which of the following is NOT a solid dosage form for oral administration?

Accepted Answer

Injection

Answer

Tablet

Answer

Capsule

Answer

Powder

Question 14

In the manufacturing of solid dosage forms, which step typically employs a high-shear granulator?

Accepted Answer

Wet granulation

Answer

Dry mixing

Answer

Compression

Question 15

Which of the following is NOT a commonly employed method for the production of compressed tablets?

Accepted Answer

Extrusion

Answer

Wet granulation

Answer

Direct compression

Answer

Dry granulation

Question 16

The primary function of a disintegrant in a tablet formulation is to:

Accepted Answer

Promote tablet disintegration into smaller particles

Answer

Lubricate tablet surfaces

Answer

Enhance drug absorption

Answer

Increase tablet hardness

Question 17

Which of the following is NOT a type of powder dosage form?

Accepted Answer

Suspension

Answer

Effervescent powder

Answer

Oral powder

Answer

Inhalation powder

Question 18

In inhalation powders, the particle size of the powder is critical because it influences:

Accepted Answer

The site of drug deposition within the respiratory system

Answer

The taste of the powder

Answer

The solubility of the drug

Question 19

Compared to liquid dosage forms, a prominent advantage of solid dosage forms is their:

Accepted Answer

Enhanced stability

Answer

Faster onset of action

Answer

Lower manufacturing cost

Answer

Improved patient compliance

Question 20

The primary purpose of granulating a powder mixture before tablet compression is to:

Accepted Answer

Enhance flowability and compressibility

Answer

Increase particle size

Answer

Improve tablet disintegration

Answer

Minimize dust formation

Question 21

The dissolution rate of a drug from a tablet is primarily affected by its:

Accepted Answer

Surface area

Answer

Hardness

Answer

Density

Answer

Mass

Question 22

Which tablet evaluation method measures the force required to break a tablet?

Accepted Answer

Tensile strength test

Answer

Weight variation test

Answer

Friability test

Answer

Disintegration test

Question 23

A powder intended for inhalation is characterized by:

Accepted Answer

Fine particle size and low density

Answer

Coarse particle size and high density

Answer

Coarse particle size and low density

Answer

Large particle size and high density

Question 24

The purpose of a disintegration test for tablets is to ensure that the tablet:

Accepted Answer

Breaks down into smaller particles within a prescribed time frame

Answer

Remains intact for an extended period

Answer

Dissolves completely within a specified time frame

Question 25

Which manufacturing technique is employed to produce tablets with a biphasic drug release profile?

Accepted Answer

Coating

Answer

Compression

Answer

Extrusion

Answer

Molding

Question 26

The friability test is used to assess the:

Accepted Answer

Resistance of a tablet to chipping or breaking

Answer

Hardness of a tablet

Answer

Dissolution rate of a tablet

Answer

Solubility of a tablet