Dosage Form Design Factors: Master the Key Influences

Question 1

Compared to immediate-release dosage forms, what is a potential disadvantage of controlled-release dosage forms?

Accepted Answer

Higher risk of rapid drug release

Answer

Less frequent dosing

Answer

Enhanced patient adherence

Answer

Lower chance of stomach upset

Question 2

Which administration route leads to the fastest drug absorption?

Accepted Answer

Intravenous

Answer

Oral

Answer

Transdermal

Answer

Intramuscular

Question 3

Which excipient is commonly employed to improve drug substance stability?

Accepted Answer

Butylated hydroxyanisole (BHA)

Answer

Lactose monohydrate

Answer

Magnesium stearate

Answer

Sodium chloride

Question 4

Which of the following is NOT a type of modified-release dosage form?

Accepted Answer

Immediate-release systems

Answer

Matrix systems

Answer

Reservoir systems

Answer

Transdermal patches

Question 5

Which of the following is NOT a primary consideration in dosage form design?

Accepted Answer

Financial constraints

Answer

Route of administration

Answer

Desired release profile

Answer

Stability of the drug substance

Question 6

What is the primary objective of using enteric coatings in dosage form design?

Accepted Answer

To protect the drug from gastric acid

Answer

To enhance drug absorption in the small intestine

Answer

To reduce drug side effects

Answer

To increase drug release time

Question 7

Which factors are crucial in selecting the most suitable route of administration for a given drug?

Accepted Answer

Physicochemical properties of the drug (e.g., solubility, stability), and patient-specific factors (e.g., age, health status).

Answer

Dosage form, excipients used, and the specific manufacturing process.

Answer

The intended therapeutic outcome and the marketed product.

Question 8

Which factors are crucial when designing a dosage form that prioritizes the patient's needs?

Accepted Answer

Patient preferences

Accepted Answer

Compliance

Accepted Answer

Lifestyle factors

Answer

Cost

Question 9

Which of the following is a critical factor that is NOT taken into consideration during dosage form design?

Accepted Answer

The patient's personality

Answer

The intended administration route

Answer

The stability profile of the active ingredient

Answer

The solubility of the drug

Question 10

What is the primary function of a disintegrant in a solid dosage form?

Accepted Answer

To facilitate the breakup of the dosage form in the gastrointestinal tract

Answer

To enhance the absorption of the drug

Answer

To improve the taste of the dosage form

Answer

To reduce the toxicity of the drug

Question 11

Which device is commonly used for the controlled delivery of insulin?

Accepted Answer

Implantable pump

Answer

Transdermal patch

Answer

Nasal spray

Answer

Suppository

Question 12

In the United Kingdom, which regulatory body is responsible for approving new medications?

Accepted Answer

Medicines and Healthcare products Regulatory Agency (MHRA)

Answer

Food and Drug Administration (FDA)

Answer

European Medicines Agency (EMA)

Answer

National Institute for Health and Care Excellence (NICE)

Question 13

Which of the following excipients is commonly used to prolong drug release in matrix tablets?

Accepted Answer

Hydroxypropyl methylcellulose (HPMC)

Answer

Starch

Answer

Lactose

Answer

Talc

Question 14

What is the goal of drug targeting in dosage form design?

Accepted Answer

To deliver the drug to the specific site of action

Answer

To minimize side effects

Answer

To improve drug absorption

Answer

To prolong drug release

Question 15

Which of the following excipients is commonly used as a binder in tablet formulation?

Accepted Answer

Starch

Answer

Magnesium stearate

Answer

Talc

Answer

Silicon dioxide

Question 16

What is the purpose of granulating a drug substance before tableting?

Accepted Answer

To improve flowability

Answer

To increase drug solubility

Answer

To reduce tablet size

Answer

To enhance tablet appearance

Question 17

Which of the following dosage forms is most suitable for administering a drug that is rapidly absorbed and requires frequent dosing?

Accepted Answer

Immediate-release capsule

Answer

Sustained-release tablet

Answer

Intravenous injection

Answer

Transdermal patch

Question 18

Which of the following factors is **NOT** typically considered when designing a dosage form?

Accepted Answer

The cost of manufacturing

Answer

The desired release profile of the drug

Answer

The intended route of administration

Answer

The chemical stability of the drug substance

Question 19

When designing an oral dosage form, what is the **most critical** factor to consider?

Accepted Answer

The bioavailability of the drug

Answer

The overall size of the dosage form

Answer

The manufacturing cost of the dosage form

Answer

The taste of the dosage form

Question 20

A drug with rapid absorption and a short half-life would be most appropriately formulated as which type of release profile?

Accepted Answer

Immediate release

Answer

Delayed release

Answer

Targeted release

Answer

Sustained release

Question 21

Which excipient is commonly employed to enhance the solubility of a poorly water-soluble drug?

Accepted Answer

Polysorbate 80

Answer

Starch

Answer

Lactose

Answer

Magnesium stearate

Question 22

What is a key advantage of using a coated tablet?

Accepted Answer

It can mask the unpleasant taste of the drug

Answer

It can effectively reduce drug side effects

Answer

It can significantly increase drug absorption

Answer

It can prolong the drug's release over a longer period

Question 23

What is a mandatory regulatory requirement for all dosage forms?

Accepted Answer

They must be safe and effective for their intended use

Answer

They must be aesthetically pleasing in appearance

Answer

They must be easy and efficient to manufacture

Answer

They must be affordable and accessible to patients

Question 24

What is a recent trend gaining significant attention in dosage form design?

Accepted Answer

The incorporation of nanotechnology

Answer

The use of natural excipients

Answer

The use of traditional manufacturing methods