Antipsychotics for Schizophrenia: Master Pharmacology with Online Quizzes

Question 1

Identify the potential adverse effect associated with clozapine:

Accepted Answer

Agranulocytosis

Answer

Tardive dyskinesia

Answer

Hyperprolactinemia

Answer

Weight loss

Question 2

What is the primary indication for the use of antipsychotics?

Accepted Answer

Schizophrenia

Answer

Bipolar disorder

Answer

Depression

Answer

Anxiety disorders

Question 3

What is the most common extrapyramidal side effect of antipsychotics?

Accepted Answer

Akathisia

Answer

Dystonia

Answer

Bradykinesia

Answer

Tremor

Question 4

What is the role of clozapine in the treatment of schizophrenia?

Accepted Answer

Treatment of treatment-resistant schizophrenia

Answer

Prevention of tardive dyskinesia

Answer

Adjunctive therapy to other antipsychotics

Answer

First-line treatment for acute psychotic episodes

Question 5

Which mechanism of action is primarily associated with typical antipsychotics?

Accepted Answer

Antagonism of dopamine D2 receptors

Answer

Agonism of serotonin 5-HT2A receptors

Answer

Inhibition of norepinephrine reuptake

Answer

Enhancement of GABAergic neurotransmission

Question 6

Which of the following is a typical antipsychotic commonly prescribed for the treatment of schizophrenia?

Accepted Answer

Chlorpromazine

Answer

Clozapine

Answer

Olanzapine

Answer

Risperidone

Question 7

What is the primary mechanism of action of atypical antipsychotics?

Accepted Answer

Predominant dopamine D2 receptor blockade, with additional antagonism at serotonin (5-HT2) receptors

Answer

Selective serotonin reuptake inhibition

Answer

Norepinephrine reuptake inhibition

Answer

Potentiation of gamma-aminobutyric acid (GABA) neurotransmission

Question 8

Which neurotransmitter is primarily targeted by most antipsychotic medications?

Accepted Answer

Dopamine

Answer

Serotonin

Answer

Norepinephrine

Answer

Glutamate

Question 9

What is the term for a lack of response to adequate antipsychotic treatment?

Accepted Answer

Treatment resistance

Answer

Symptom exacerbation

Answer

Tardive dysphoria

Answer

Neuroleptic malignant syndrome

Question 10

Which of the following is NOT a known risk factor for schizophrenia?

Accepted Answer

High socioeconomic status

Answer

Family history

Answer

Substance abuse

Answer

Stress

Question 11

In which phase of schizophrenia are antipsychotics primarily used?

Accepted Answer

Active psychotic

Answer

Prodromal

Answer

Residual

Question 12

Which pharmacological strategy is commonly employed to specifically manage the extrapyramidal side effects of typical antipsychotics?

Accepted Answer

Administering antimuscarinic agents

Answer

Increasing the dose of antipsychotic

Answer

Switching to an atypical antipsychotic

Answer

Reducing the frequency of antipsychotic administration

Question 13

Which of the following is the primary mechanism of action of typical antipsychotics?

Accepted Answer

Dopamine receptor blockade

Answer

Serotonin receptor blockade

Answer

Muscarinic receptor blockade

Answer

Histamine receptor blockade

Question 14

Which of the following is NOT classified as an atypical antipsychotic?

Accepted Answer

Haloperidol

Answer

Clozapine

Answer

Olanzapine

Answer

Risperidone

Question 15

Which adverse effect is commonly associated with typical antipsychotics but less so with atypical antipsychotics?

Accepted Answer

Tardive dyskinesia

Answer

Weight gain

Answer

Hypertension

Answer

QTc prolongation

Question 16

Which of the following is a potential benefit of clozapine in the treatment of schizophrenia?

Accepted Answer

Effectiveness in treatment-resistant cases

Answer

Absence of extrapyramidal side effects

Answer

Low risk of tardive dyskinesia

Answer

Reduced risk of seizures

Question 17

Which of the following is NOT a symptom of schizophrenia?

Accepted Answer

Mania

Answer

Hallucinations

Answer

Delusions

Answer

Disorganized speech

Question 18

Which of the following antipsychotics has a lower risk of causing hyperlipidemia?

Accepted Answer

Ziprasidone

Answer

Haloperidol

Answer

Olanzapine

Answer

Risperidone

Question 19

In the long-term management of schizophrenia, why is it essential to continuously monitor and adjust the dosage of antipsychotics?

Accepted Answer

To evaluate treatment effectiveness and adjust dosage accordingly

Answer

To prevent long-term side effects

Answer

To ensure medication adherence

Answer

To detect and manage drug interactions

Question 20

Which of the following antipsychotics has a significantly lower risk of causing extrapyramidal side effects (EPS) compared to typical antipsychotics?

Accepted Answer

Atypical antipsychotics

Answer

Typical antipsychotics

Answer

Both typical and atypical antipsychotics

Answer

Neither typical nor atypical antipsychotics

Question 21

Which of the following is the primary mechanism of action of atypical antipsychotics?

Accepted Answer

Blockade of dopamine D2 and serotonin 5-HT2A receptors

Answer

Blockade of dopamine D2 receptors only

Answer

Blockade of serotonin 5-HT2A receptors only

Question 22

Which of the following is a potential long-term adverse effect of typical antipsychotics?

Accepted Answer

Tardive dyskinesia

Answer

Weight gain

Answer

Diarrhea

Answer

Anxiety

Question 23

Which of the following is a common positive symptom of schizophrenia?

Accepted Answer

Hallucinations

Answer

Anxiety

Answer

Bipolar disorder

Answer

Depression

Question 24

Which of the following is an example of a butyrophenone, a type of typical antipsychotic?

Accepted Answer

Haloperidol

Answer

Amisulpride

Answer

Clozapine

Answer

Olanzapine

Question 25

Which of the following is a potential strategy for improving medication adherence in schizophrenia?

Accepted Answer

Long-acting injectable antipsychotics

Answer

Patient education only

Answer

Cognitive-behavioral therapy only

Answer

Motivational interviewing only