Drugs Used in Inflammatory Bowel Disease: Interactive Learning Quizzes

Question 1

When monitoring a patient with IBD receiving immunosuppressant therapy, which laboratory test is of primary importance?

Accepted Answer

Complete blood count

Answer

Liver function tests

Answer

Renal function tests

Answer

Serum drug level monitoring

Question 2

Which topical corticosteroid is typically used in the management of Ulcerative Colitis?

Accepted Answer

Budesonide

Answer

Prednisolone

Answer

Methylprednisolone

Answer

Dexamethasone

Question 3

What is the primary therapeutic application of mesalazine enemas?

Accepted Answer

Treating acute flares of Ulcerative Colitis

Answer

Maintaining remission in Crohn's Disease

Answer

Preventing pouchitis after ileal pouch anal anastomosis

Answer

Inducing remission in moderately active Crohn's Disease

Question 4

Which potential adverse effect is associated with 5-aminosalicylic acid use?

Accepted Answer

Interstitial nephritis

Answer

Leukopenia

Answer

Pancreatitis

Answer

Hepatotoxicity

Question 5

Which of the following is recommended as the first-line therapy for mild-to-moderate ulcerative colitis, according to established treatment guidelines?

Accepted Answer

5-Aminosalicylic acid

Answer

Corticosteroids

Answer

Immunosuppressants

Question 6

Which of the following is NOT a mechanism of action of 5-aminosalicylic acid (5-ASA) in Inflammatory Bowel Disease (IBD)?

Accepted Answer

Blockade of TNF-α

Answer

Inhibition of prostaglandin synthesis

Answer

Suppression of leukotriene production

Answer

Inhibition of neutrophil migration

Question 7

Which immunosuppressant is typically the first-line therapy for moderate to severe Crohn's disease?

Accepted Answer

Azathioprine

Answer

Methotrexate

Answer

Infliximab

Answer

Adalimumab

Question 8

Which of the following is a characteristic of the prodrug form of azathioprine?

Accepted Answer

It is inactive until metabolized in the liver

Answer

It is more soluble than the active form

Answer

It has a longer half-life than the active form

Answer

It is less toxic than the active form

Question 9

Which of the following is NOT a potential adverse effect of infliximab?

Accepted Answer

Hemolytic anemia

Answer

Infusion reactions

Answer

Increased susceptibility to infections

Answer

Lupus-like syndrome

Question 10

How is 5-aminosalicylic acid's bioavailability impacted when taken orally?

Accepted Answer

Released locally in the colon by colonic bacterial enzymes.

Answer

Poorly absorbed in the small intestine, resulting in high systemic levels.

Answer

Metabolized extensively in the liver, reducing its availability in the colon.

Answer

Quickly excreted in the urine, leading to a short duration of action.

Question 11

Which monitoring plan is essential for patients on long-term immunosuppressant therapy for Inflammatory Bowel Disease?

Accepted Answer

Monthly complete blood count, liver, and kidney function tests

Answer

Annual chest X-ray and Mantoux test

Answer

Assessment of fecal calprotectin and C-reactive protein every three months

Answer

Monitoring only when symptoms appear

Question 12

In the treatment of Inflammatory Bowel Disease, what is the primary use of corticosteroids?

Accepted Answer

Inducing and maintaining remission in ulcerative colitis and Crohn's disease

Answer

Treating Crohn's disease exclusively

Answer

Serving as first-line therapy for all Inflammatory Bowel Disease patients

Answer

Managing pouchitis exclusively

Question 13

Which of the following is recommended as the first-line drug treatment for mild to moderate ulcerative colitis?

Accepted Answer

5-aminosalicylic acid

Answer

Prednisolone

Answer

Budesonide

Answer

Azathioprine

Question 14

Which of the following is a known adverse effect of oral corticosteroids commonly used in Inflammatory Bowel Disease?

Accepted Answer

Cushingoid features

Answer

Anaphylaxis

Answer

Thrombocytopenia

Answer

Hepatotoxicity

Question 15

When are immunosuppressants primarily indicated in the management of Inflammatory Bowel Disease?

Accepted Answer

Severe, steroid-refractory disease

Answer

Maintenance of remission

Answer

Mild to moderate disease

Answer

Induction of remission

Question 16

Which parameter is primarily monitored to assess methotrexate toxicity?

Accepted Answer

Full blood count

Answer

Electrocardiogram

Answer

Renal function tests

Answer

Liver function tests

Question 17

Which of the following is recognized as a potential adverse effect associated with infliximab use?

Accepted Answer

Increased risk of infection

Answer

Cushingoid features

Answer

Thrombocytopenia

Answer

Hepatotoxicity

Question 18

What is the recommended route of administration for vedolizumab?

Accepted Answer

Intravenous infusion

Answer

Subcutaneous injection

Answer

Rectal enema

Answer

Oral administration

Question 19

Which of the following factors plays a significant role in determining the choice of drug therapy for Inflammatory Bowel Disease?

Accepted Answer

Disease severity

Answer

Patient's gender

Answer

Patient's age

Answer

Patient's weight

Question 20

What is the ultimate goal of treatment in Inflammatory Bowel Disease?

Accepted Answer

Induction and maintenance of remission

Answer

Improvement of quality of life

Answer

Prevention of surgery

Answer

Cure of the disease

Question 21

What is a key difference between sulfasalazine and mesalazine in treating inflammatory bowel disease?

Accepted Answer

Sulfasalazine has a higher risk of side effects compared to mesalazine.

Answer

Sulfasalazine is generally more effective than mesalazine in inducing remission.

Answer

Mesalazine is only effective for ulcerative colitis, while sulfasalazine treats both ulcerative colitis and Crohn's disease.

Question 22

A patient with ulcerative colitis experiences a severe flare-up. Which corticosteroid formulation would be the MOST appropriate for immediate management?

Accepted Answer

Intravenous hydrocortisone

Answer

Inhaled beclometasone

Answer

Oral prednisolone

Answer

Topical budesonide

Question 23

How does azathioprine work in treating inflammatory bowel disease?

Accepted Answer

It inhibits purine synthesis, suppressing lymphocyte proliferation.

Answer

It binds to glucocorticoid receptors, mimicking the effects of corticosteroids.

Answer

It blocks tumor necrosis factor-alpha (TNF-α), reducing inflammation.

Question 24

What is a common side effect associated with long-term corticosteroid use for inflammatory bowel disease?

Accepted Answer

Osteoporosis

Answer

Bradycardia

Answer

Hypotension

Answer

Hypoglycemia

Question 25

A Crohn's disease patient experiences severe nausea while taking azathioprine. Which alternative immunosuppressant could be considered?

Accepted Answer

Methotrexate

Answer

Sulfasalazine

Answer

Budesonide

Question 26

When are biologic therapies typically used in inflammatory bowel disease?

Accepted Answer

Biologics are generally reserved for moderate to severe cases that haven't responded to conventional treatments.

Answer

Biologics are the first-line treatment for all patients with inflammatory bowel disease.

Question 27

Which laboratory test is crucial before initiating azathioprine therapy?

Accepted Answer

Thiopurine methyltransferase (TPMT) activity

Answer

Liver function tests (LFTs)

Answer

C-reactive protein (CRP)

Question 28

What is a potential advantage of using budesonide over prednisolone in Crohn's disease treatment?

Accepted Answer

Budesonide has a lower risk of systemic side effects due to its extensive first-pass metabolism.

Answer

Budesonide can be administered intravenously for rapid symptom control.

Answer

Budesonide is generally more effective than prednisolone in inducing remission.

Question 29

Infliximab, adalimumab, and golimumab belong to which class of medications used for inflammatory bowel disease?

Accepted Answer

Tumor necrosis factor-alpha (TNF-α) inhibitors

Answer

Interleukin-1 inhibitors

Answer

Phosphodiesterase-4 inhibitors

Answer

Janus kinase (JAK) inhibitors