Drugs Used in Asthma: Master the Pharmacology of Asthma Medications

Question 1

Which leukotriene modifier is a prodrug that is converted to its active form in the lungs?

Accepted Answer

Montelukast

Answer

Zafirlukast

Answer

Pranlukast

Answer

Zileuton

Question 2

Which of the following adverse effects is most commonly associated with the use of leukotriene modifiers in asthma?

Accepted Answer

Gastrointestinal disturbances

Answer

Liver damage

Answer

Headache

Answer

Bronchospasm

Question 3

What is the mechanism of action of phosphodiesterase-4 inhibitors in asthma?

Accepted Answer

Inhibit the breakdown of cAMP

Answer

Activate adenylyl cyclase

Answer

Block histamine receptors

Answer

Stimulate beta2-receptors

Question 4

Which of the following is a potential interaction between inhaled corticosteroids and other medications?

Accepted Answer

Increased risk of low potassium levels with diuretics

Answer

Enhanced bronchodilation with beta2-agonists

Answer

Reduced effectiveness with antibiotics

Answer

Increased risk of bleeding with blood thinners

Question 5

What is the recommended route of administration for cromolyn sodium in asthma?

Accepted Answer

Inhalation

Answer

Oral

Answer

Intravenous injection

Answer

Rectal administration

Question 6

In asthma management, monitoring lung function and asthma control is crucial. What is the primary purpose of these monitoring parameters?

Accepted Answer

Assessing response to therapy and guiding treatment adjustments

Answer

Establishing an asthma diagnosis and distinguishing it from other conditions

Answer

Predicting future asthma exacerbations and their severity

Answer

Selecting the most appropriate medication for a specific patient

Question 7

Which inhaled corticosteroid is considered the most effective for the treatment of asthma?

Accepted Answer

Fluticasone propionate

Answer

Salmeterol

Answer

Montelukast

Answer

Cromolyn sodium

Question 8

What is the primary pharmacological action of leukotriene modifiers in the treatment of asthma?

Accepted Answer

Inhibit the release of leukotrienes

Answer

Block beta-adrenergic receptors

Answer

Increase cAMP levels

Answer

Activate phosphodiesterase

Question 9

Which of the following adverse effects is most often associated with the use of cromolyn sodium?

Accepted Answer

Hoarseness

Answer

Tremor

Answer

Tachyphylaxis

Answer

Bronchospasm

Question 10

What is the primary role of inhaled corticosteroids in the management of asthma?

Accepted Answer

Controller medication

Answer

Rescue medication

Answer

As needed medication

Answer

Long-term prophylaxis

Question 11

Which of the following drugs is classified as a long-acting beta-agonist used in the treatment of asthma?

Accepted Answer

Salmeterol

Answer

Terbutaline

Answer

Albuterol

Answer

Cromolyn sodium

Question 12

What is the primary mechanism of action of inhaled beta-agonists?

Accepted Answer

Increase cAMP levels

Answer

Block histamine receptors

Answer

Inhibit phosphodiesterase

Answer

Stimulate mucus secretion

Question 13

Which of the following is NOT a potential adverse effect of salmeterol?

Accepted Answer

Hypoglycemia

Answer

Tachycardia

Answer

Tremor

Answer

Headache

Question 14

Which of the following is the primary mechanism of action of inhaled corticosteroids in asthma?

Accepted Answer

Suppression of pro-inflammatory cytokine production

Answer

Relaxation of airway smooth muscle

Answer

Inhibition of mast cell degranulation

Answer

Blockade of leukotriene receptors

Question 15

Which leukotriene modifier acts as a competitive antagonist at the leukotriene D4 receptor?

Accepted Answer

Montelukast

Answer

Zafirlukast

Answer

Zileuton

Answer

Pranlukast

Question 16

Which adverse effect is most commonly associated with cromolyn sodium therapy in asthma?

Accepted Answer

Bronchospasm

Answer

Cardiovascular events

Answer

Adrenal suppression

Answer

Hepatic toxicity

Question 17

What is the primary pharmacological action of theophylline in asthma?

Accepted Answer

Bronchodilation

Answer

Anti-inflammatory action

Answer

Mast cell stabilization

Answer

Leukotriene inhibition

Question 18

Which factor is most important to consider when selecting an asthma medication for a specific patient?

Accepted Answer

Severity of asthma

Answer

Patient's age

Answer

Co-existing medical conditions

Answer

Availability of generic options

Question 19

In asthma, inhaled corticosteroids primarily work by:

Accepted Answer

Inhibiting phosphodiesterase-4

Answer

Activating adenylyl cyclase

Answer

Stimulating beta-2 adrenoreceptors

Answer

Antagonizing leukotriene receptors

Question 20

Zafirlukast is an example of a:

Accepted Answer

Leukotriene modifier

Answer

Beta-2 agonist

Answer

Inhaled corticosteroid

Answer

Cromone

Question 21

The main adverse effect associated with cromolyn sodium is:

Accepted Answer

Bronchitis

Answer

Tachycardia

Answer

Hypokalemia

Answer

Tremor

Question 22

The most common type of adverse effect associated with leukotriene modifiers is:

Accepted Answer

Gastrointestinal upset

Answer

Headache

Answer

Bronchitis

Answer

Tremor