T Cell Biology Quizzes: Master Adaptive Immunity

Question 1

Which of the following is NOT a step in T cell development?

Accepted Answer

Differentiation into memory T cells

Answer

Positive selection

Answer

Negative selection

Answer

Commitment to the T cell lineage

Question 2

Which of the following is a characteristic of memory T cells?

Accepted Answer

Long-lived cells with rapid recall responses

Answer

Specialized in killing virally infected cells

Answer

Tolerant to self-antigens

Answer

Secrete high levels of antibodies

Question 3

Which of the following is NOT a mechanism of T cell tolerance?

Accepted Answer

Cytokine production

Answer

Clonal deletion

Answer

Clonal anergy

Answer

Suppressor T cell activity

Question 4

What is the primary role of Tregs (regulatory T cells)?

Accepted Answer

To suppress immune responses and maintain self-tolerance

Answer

To activate other immune cells

Answer

To produce cytokines that promote inflammation

Answer

To recognize and destroy cancer cells

Question 5

Which of the following is a characteristic of the adaptive immune response?

Accepted Answer

Memory to previous infections

Answer

Specificity for a wide range of pathogens

Answer

Immediate response to infection

Answer

Involvement of non-specific immune cells

Question 6

Where do T cells undergo maturation and positive selection?

Accepted Answer

Thymus

Answer

Bone marrow

Answer

Spleen

Answer

Lymph nodes

Question 7

Which cytokine primarily activates cytotoxic T cells?

Accepted Answer

Interleukin-2 (IL-2)

Answer

Interleukin-4 (IL-4)

Answer

Interleukin-6 (IL-6)

Answer

Interleukin-10 (IL-10)

Question 8

Which type of helper T cell primarily activates B cells?

Accepted Answer

Tfh

Answer

Th1

Answer

Th2

Answer

Th17

Question 9

Which type of T cell has a crucial role in suppressing immune responses?

Accepted Answer

Regulatory T cells

Answer

Cytotoxic T cells

Answer

Helper T cells

Answer

Memory T cells

Question 10

Which laboratory technique is commonly used to measure T cell activation and proliferation?

Accepted Answer

Flow cytometry

Answer

Western blotting

Answer

Enzyme-linked immunosorbent assay (ELISA)

Answer

Electrophoresis

Question 11

Which of the following is the primary role of cytotoxic T cells (CTLs)?

Accepted Answer

To directly kill infected or cancerous cells

Answer

To secrete cytokines that activate other immune cells

Answer

To present antigens to B cells

Answer

To suppress immune responses

Question 12

Which cytokine is primarily responsible for the differentiation of naive T cells into Th1 cells?

Accepted Answer

Interleukin-12 (IL-12)

Answer

Interleukin-2 (IL-2)

Answer

Interleukin-4 (IL-4)

Answer

Interferon-gamma (IFN-γ)

Question 13

Which of the following molecules is involved in the negative regulation of T cell activation?

Accepted Answer

CTLA-4

Answer

CD28

Answer

CD3

Answer

MHC I

Question 14

Which of the following is a key feature of T cell memory?

Accepted Answer

Rapid and robust response to re-exposure to antigen

Answer

Generation of effector T cells that can recognize a wide range of antigens

Answer

Ability to suppress immune responses

Answer

Production of antibodies that neutralize pathogens

Question 15

Which of the following techniques is commonly used to study T cell activation and differentiation?

Accepted Answer

Flow cytometry

Answer

Western blotting

Answer

Immunohistochemistry

Answer

Electrophysiology

Question 16

Which of the following is a defining characteristic of T cells?

Accepted Answer

Express the CD3 receptor complex

Answer

Can be activated directly by antigens

Answer

Secrete antibodies

Answer

Are phagocytic

Question 17

What is the primary function of cytotoxic T cells (Tc cells)?

Accepted Answer

Eliminate infected or cancerous cells

Answer

Activate macrophages

Answer

Help B cells differentiate into plasma cells

Answer

Produce antibodies

Question 18

What is the mechanism of action of helper T cells (Th cells)?

Accepted Answer

Release cytokines to stimulate other immune cells

Answer

Directly kill infected cells

Answer

Produce antibodies

Answer

Present antigens to B cells

Question 19

Which type of helper T cell specifically promotes antibody production by B cells?

Accepted Answer

Th2 cells

Answer

Th17 cells

Answer

Th1 cells

Answer

Treg cells

Question 20

What is the primary function of MHC molecules in T cell activation?

Accepted Answer

Present processed antigens to T cells

Answer

Produce cytokines

Answer

Destroy infected cells

Answer

Activate B cells

Question 21

Which type of immune cell plays a key role in regulating T cell activity?

Accepted Answer

Regulatory T cells (Treg cells)

Answer

Helper T cells

Answer

Cytotoxic T cells

Answer

B cells

Question 22

What is the process by which immature T cells undergo selection and maturation?

Accepted Answer

Thymocyte development

Answer

Antibody production

Answer

T cell activation

Answer

B cell differentiation

Question 23

What is the significance of T cell memory?

Accepted Answer

Enables rapid and effective immune responses to previously encountered pathogens

Answer

Prevents the development of autoimmune diseases

Answer

Promotes antibody production by B cells