Anti-Asthmatic Drugs Pharmacology: Online Quizzes and Learning

Question 1

Which of the following is NOT a mechanism of action of inhaled corticosteroids in the treatment of asthma?

Accepted Answer

Increase production of beta-2 agonists

Answer

Decrease airway inflammation

Answer

Inhibit histamine release

Answer

Enhance mucociliary clearance

Question 2

Which of the following is the primary mechanism of action of inhaled corticosteroids (ICSs)?

Accepted Answer

Reduction of airway inflammation by binding to glucocorticoid receptors

Answer

Inhibition of phosphodiesterase-4 (PDE-4) enzyme

Answer

Inhibition of leukotriene synthesis

Answer

Bronchodilation via stimulation of β2-adrenergic receptors

Question 3

Montelukast belongs to which class of anti-asthmatic drugs?

Accepted Answer

Leukotriene inhibitors (LTIs)

Answer

Inhaled corticosteroids (ICSs)

Answer

Monoclonal antibodies (mAbs)

Answer

β2-agonists

Question 4

Which monoclonal antibody is specifically used to treat severe asthma with IgE-mediated allergic triggers?

Accepted Answer

Omalizumab

Answer

Benralizumab

Answer

Dupilumab

Answer

Reslizumab

Question 5

Which of the following is a potential adverse effect of long-term ICS use?

Accepted Answer

Osteoporosis

Answer

Cushing's syndrome

Answer

Tachycardia

Answer

Hypertension

Question 6

Which characteristic is crucial for a β2-agonist used in the treatment of acute asthma?

Accepted Answer

Rapid onset of action within minutes

Answer

Long duration of action (12 hours or more)

Answer

High affinity for β1-adrenergic receptors

Answer

Ability to prevent airway inflammation

Question 7

In managing moderate to severe persistent asthma, which drug combination is commonly employed?

Accepted Answer

ICS and long-acting β2-agonist (LABA)

Answer

ICS and leukotriene inhibitor (LTI)

Answer

ICS, LABA, and LTI

Answer

ICS and oral glucocorticoids

Question 8

What is the primary role of cromolyn sodium in asthma management?

Accepted Answer

Prevention of mast cell degranulation and histamine release

Answer

Reversal of airway inflammation

Answer

Bronchodilation

Answer

Inhibition of leukotriene synthesis

Question 9

What is the primary mechanism of action of beta-agonists in the treatment of asthma?

Accepted Answer

Activation of beta-adrenergic receptors

Answer

Inhibition of phosphodiesterase

Answer

Blockade of muscarinic acetylcholine receptors

Answer

Stimulation of leukotriene synthesis

Question 10

Which of the following is a common use of inhaled corticosteroids in the treatment of asthma?

Accepted Answer

Long-term control of chronic asthma symptoms

Answer

Relief of acute asthma attacks

Answer

Treatment of nasal congestion

Answer

Prevention of allergic reactions

Question 11

What is the most common adverse effect associated with the use of anticholinergics in the treatment of asthma?

Accepted Answer

Dry mouth

Answer

Tachycardia

Answer

Tremor

Answer

Bronchospasm

Question 12

Which of the following interventions is the first-line treatment for acute asthma attacks?

Accepted Answer

Inhaled beta-agonists

Answer

Oral corticosteroids

Answer

Chest physiotherapy

Answer

Oxygen therapy

Question 13

What is the target enzyme for xanthine derivatives in the treatment of asthma?

Accepted Answer

Phosphodiesterase

Answer

Leukotriene synthase

Answer

Adenylyl cyclase

Answer

Acetylcholinesterase

Question 14

What is the primary goal of long-term asthma management?

Accepted Answer

Prevention of exacerbations and improvement in quality of life

Answer

Complete remission of symptoms

Answer

Reduction in medication usage

Answer

Reversal of airway remodeling

Question 15

Why is proper inhalation technique essential for the effective delivery of inhaled asthma medications?

Accepted Answer

Ensures the medication reaches the deepest parts of the lungs, maximizing its therapeutic effect.

Answer

Minimizes systemic side effects.

Answer

Improves patient compliance with medication regimens.

Answer

Reduces the risk of paradoxical bronchospasm.

Question 16

Which mechanism is primarily responsible for the bronchodilatory effects of short-acting β2-agonists in asthma treatment?

Accepted Answer

Relaxation of airway smooth muscle

Answer

Inhibition of mast cell degranulation

Answer

Stimulation of mucus secretion

Answer

Reduction of airway inflammation

Question 17

Leukotriene modifiers, such as montelukast, primarily work by:

Accepted Answer

Blocking the binding of leukotrienes to airway receptors

Answer

Preventing the production of leukotrienes

Answer

Promoting the synthesis of anti-inflammatory mediators

Answer

Inhibiting the release of histamine from mast cells

Question 18

Anticholinergic drugs in asthma primarily act by:

Accepted Answer

Blocking muscarinic receptors on airway smooth muscle

Answer

Stimulating β2-receptors on airway smooth muscle

Answer

Inhibiting the release of inflammatory mediators

Answer

Increasing the production of mucus

Question 19

Which type of asthma is most common among children?

Accepted Answer

Allergic asthma

Answer

Non-allergic asthma

Answer

Exercise-induced asthma

Answer

Occupational asthma

Question 20

What is the initial recommended step in managing an acute severe asthma exacerbation?

Accepted Answer

Administration of inhaled salbutamol

Answer

Intravenous administration of corticosteroids

Answer

High-flow oxygen therapy

Answer

Chest X-ray

Question 21

Which of the following is NOT a type of anti-asthmatic drug?

Accepted Answer

Antihypertensives

Answer

Anticholinergics

Answer

Corticosteroids

Answer

Sympathomimetics

Question 22

Which of the following mechanisms of action is NOT involved in the bronchodilating effects of β2-agonists?

Accepted Answer

Activation of muscarinic acetylcholine receptors

Answer

Activation of β2-adrenergic receptors

Answer

Inhibition of phosphodiesterase

Answer

Increase in cyclic adenosine monophosphate (cAMP)

Question 23

Which of the following drugs is a long-acting β2-agonist (LABA)?

Accepted Answer

Salmeterol

Answer

Ipratropium bromide

Answer

Salbutamol

Answer

Budesonide

Question 24

Which of the following is a potential adverse effect of theophylline?

Accepted Answer

Cardiac arrhythmias

Answer

Dry mouth

Answer

Hyperglycemia

Answer

Bronchospasm

Question 25

Which of the following drugs is a leukotriene inhibitor?

Accepted Answer

Montelukast

Answer

Salmeterol

Answer

Budesonide

Answer

Ipratropium bromide

Question 26

Which of the following inhaled corticosteroids (ICS) has the highest potency?

Accepted Answer

Fluticasone propionate

Answer

Budesonide

Answer

Ciclesonide

Answer

Beclomethasone dipropionate

Question 27

Which of the following drugs is used for the treatment of severe asthma attacks?

Accepted Answer

Systemic corticosteroids

Answer

Short-acting β2-agonists

Answer

Mast cell stabilizers

Answer

Leukotriene inhibitors

Question 28

Which of the following is a contraindication to the use of β-blockers in asthma?

Accepted Answer

Active bronchospasm

Answer

Arrhythmias

Answer

Heart failure

Answer

Hypertension

Question 29

Which of the following is an important aspect of monitoring the efficacy of anti-asthmatic drugs?

Accepted Answer

Regular assessment of lung function

Answer

Liver function tests

Answer

Blood pressure measurement

Answer

ECG monitoring