Immunotherapy Drug Pharmacology: Interactive Quizzes for Medical Students

Question 1

What is the primary mechanism of action of monoclonal antibodies in immunotherapy?

Accepted Answer

Blocking cell surface receptors

Answer

Inducing cell death

Answer

Enhancing immune cell activation

Answer

Inhibiting protein synthesis

Question 2

In oncology, which of the following is a therapeutic application of monoclonal antibodies?

Accepted Answer

Treatment of non-Hodgkin lymphoma

Answer

Prevention of organ rejection

Answer

Treatment of bacterial infections

Answer

Control of inflammation

Question 3

Which mechanism of action is NOT characteristic of monoclonal antibodies used in immunotherapy?

Accepted Answer

Inhibiting cell proliferation

Answer

Binding to specific antigens on target cells

Answer

Inducing antibody-dependent cell-mediated cytotoxicity (ADCC)

Answer

Stimulating the complement cascade

Question 4

Which checkpoint inhibitor target is primarily associated with T cell exhaustion in chronic infections and cancer?

Accepted Answer

PD-1

Answer

CTLA-4

Answer

ICOS

Answer

TIM-3

Question 5

What is a primary therapeutic application of cancer vaccines?

Accepted Answer

Immune surveillance and elimination of cancer cells

Answer

Prevention of cancer development

Answer

Treatment of advanced metastatic cancer

Answer

Suppression of autoimmune responses

Question 6

Which adverse effect is most commonly associated with the use of immune checkpoint inhibitors?

Accepted Answer

Immune-related colitis

Answer

Myelosuppression

Answer

Cardiotoxicity

Answer

Nephrotoxicity

Question 7

Which characteristic is a defining feature of monoclonal antibodies?

Accepted Answer

High specificity and affinity

Answer

Long half-life in circulation

Answer

Ability to cross the blood-brain barrier

Answer

Directly kill target cells

Question 8

What is a key mechanism of action employed by cancer vaccines?

Accepted Answer

Stimulation of cytotoxic T cells

Answer

Induction of antibody production

Answer

Inhibition of angiogenesis

Answer

Activation of natural killer cells

Question 9

Which adverse effect is associated with the use of interleukin-2 (IL-2) in immunotherapy?

Accepted Answer

Capillary leak syndrome

Answer

Myelosuppression

Answer

Cardiotoxicity

Answer

Hepatotoxicity

Question 10

Which type of immunotherapeutic drug utilizes the patient's own immune cells?

Accepted Answer

Adoptive cell therapy

Answer

Monoclonal antibodies

Answer

Checkpoint inhibitors

Answer

Cancer vaccines

Question 11

Which of the following is NOT a class of immunotherapeutic drugs used in modern medicine?

Accepted Answer

Antibiotics

Answer

Monoclonal antibodies

Answer

Checkpoint inhibitors

Answer

Cancer vaccines

Question 12

The primary mechanism of action of monoclonal antibodies in cancer immunotherapy involves:

Accepted Answer

Activating the immune system against cancer cells

Answer

Blocking cancer cell growth

Answer

Inhibiting immune checkpoints

Answer

Inducing apoptosis (programmed cell death) in cancer cells

Question 13

Which of the following is a common therapeutic use of checkpoint inhibitors in cancer treatment?

Accepted Answer

Treating various types of solid tumours

Answer

Preventing autoimmune disorders

Answer

Managing bacterial infections

Answer

Reducing inflammation

Question 14

An adverse effect associated with cancer vaccines, particularly during the initial administration, is:

Accepted Answer

Cytokine release syndrome

Answer

Anaphylaxis

Answer

Immunosuppression

Answer

Renal failure

Question 15

Immunotherapeutic drugs are used in various fields beyond oncology. Which of the following is an example of such a use?

Accepted Answer

Rheumatoid arthritis

Answer

Tuberculosis

Answer

Influenza

Question 16

Which of the following is NOT a type of monoclonal antibody based on its structure?

Accepted Answer

Peptide

Answer

Chimeric

Answer

Humanized

Answer

Bispecific

Question 17

What is the primary therapeutic use of cancer vaccines?

Accepted Answer

Prevention of cancer recurrence after surgical resection

Answer

Treatment of advanced metastatic cancer

Answer

Immunotherapy for autoimmune diseases

Answer

Management of chronic inflammatory conditions

Question 18

Which of the following adverse effects is associated with the use of immune checkpoint inhibitors?

Accepted Answer

Myocarditis

Answer

Anaphylaxis

Answer

Nausea and vomiting

Answer

Hypoglycemia

Question 19

In the context of monoclonal antibodies, what is the purpose of PEGylation?

Accepted Answer

Enhancing antibody stability

Answer

Increasing antibody specificity

Answer

Blocking antibody binding to Fc receptors

Answer

Promoting antibody penetration into tissues

Question 20

Which immune cell type is primarily targeted by CTLA-4 checkpoint inhibitors?

Accepted Answer

T cells

Answer

B cells

Answer

Natural killer cells

Answer

Dendritic cells

Question 21

What is the mechanism of action of agonistic monoclonal antibodies?

Accepted Answer

They bind and activate their target receptor.

Answer

They block inhibitory signals.

Answer

They enhance antigen presentation.

Answer

They deplete immune cells.

Question 22

Regarding the use of cancer vaccines, which of the following statements is accurate?

Accepted Answer

They are typically combined with other immunotherapeutic approaches.

Answer

They are effective against all types of cancer.

Answer

They can be used as a standalone treatment.

Answer

They have no role in cancer prevention.