Antiulcer Drugs Pharmacology: Comprehensive Quizzes for MBBS Students

Question 1

Which mechanism best describes how proton pump inhibitors (PPIs) work to reduce stomach acid secretion?

Accepted Answer

Blocking the H+/K+-ATPase pump in stomach cells

Answer

Increasing mucus production in the stomach lining

Answer

Neutralizing stomach acid

Answer

Blocking histamine receptors on stomach cells

Question 2

Which of the following is not an antiulcer drug?

Accepted Answer

Ibuprofen

Answer

Omeprazole

Answer

Ranitidine

Answer

Sucralfate

Question 3

Which of the following drugs is an example of a selective H2-receptor antagonist?

Accepted Answer

Ranitidine

Answer

Omeprazole

Answer

Cimetidine

Answer

Sucralfate

Question 4

What is the primary therapeutic indication for sucralfate?

Accepted Answer

Treatment of peptic ulcers

Answer

Treatment of gastroesophageal reflux disease

Answer

Prevention of stress ulcers

Answer

Treatment of Zollinger-Ellison syndrome

Question 5

Which of the following patients is most likely to benefit from triple therapy for Helicobacter pylori eradication?

Accepted Answer

Patient with a history of peptic ulcer disease

Answer

Patient with non-erosive gastritis

Answer

Patient with atrophic gastritis

Answer

Patient with gastric cancer

Question 6

What is the key difference between a proton pump inhibitor and a H2-receptor antagonist?

Accepted Answer

Proton pump inhibitors are more effective in reducing gastric acid secretion.

Answer

H2-receptor antagonists have a longer duration of action.

Answer

Proton pump inhibitors are more likely to cause adverse effects.

Answer

H2-receptor antagonists are more expensive than proton pump inhibitors.

Question 7

Which of the following drugs is contraindicated in patients with significant renal impairment?

Accepted Answer

Omeprazole

Answer

Ranitidine

Answer

Famotidine

Answer

Sucralfate

Question 8

What is the recommended duration of treatment with sucralfate for active duodenal ulcers?

Accepted Answer

6 weeks

Answer

4 weeks

Answer

8 weeks

Answer

12 weeks

Question 9

Proton pump inhibitors (PPIs) primarily act by:

Accepted Answer

Irreversibly binding to the H+/K+-ATPase pump and inhibiting gastric acid secretion

Answer

Blocking histamine-2 receptors in parietal cells

Answer

Forming a physical barrier on the gastric mucosa

Answer

Neutralizing gastric acid

Question 10

A common adverse effect associated with H2-receptor antagonists is:

Accepted Answer

Hypergastrinemia

Answer

Hepatotoxicity

Answer

Constipation

Answer

Drug-induced lupus

Question 11

Sucralfate's antiulcer effect is primarily attributed to its ability to:

Accepted Answer

Form a protective layer over ulcerated areas

Answer

Promote prostaglandin synthesis

Answer

Inhibit parietal cell function

Answer

Stimulate mucosal blood flow

Question 12

Which factor is NOT a known risk factor for developing peptic ulcer disease?

Accepted Answer

Exercise

Answer

Helicobacter pylori infection

Answer

Nonsteroidal anti-inflammatory drug (NSAID) use

Answer

Smoking

Question 13

The recommended first-line therapy for peptic ulcer disease caused by Helicobacter pylori is:

Accepted Answer

Triple therapy with a PPI, amoxicillin, and clarithromycin

Answer

Quadruple therapy with a PPI, bismuth, metronidazole, and tetracycline

Answer

Monotherapy with a PPI

Answer

Monotherapy with antibiotics

Question 14

Which class of antiulcer drugs is most effective in treating gastric ulcers?

Accepted Answer

Proton pump inhibitors (PPIs)

Answer

H2-receptor antagonists

Answer

Sucralfate

Answer

Antacids

Question 15

What is the primary way that proton pump inhibitors reduce gastric acid secretion?

Accepted Answer

Inhibiting the H+/K+-ATPase pump on parietal cells

Answer

Neutralizing gastric acid

Answer

Reducing the production of gastric mucus

Answer

Stimulating the synthesis of prostaglandins

Question 16

Which of the following is the most commonly reported adverse effect associated with the use of sucralfate?

Accepted Answer

Constipation

Answer

Diarrhea

Answer

Nausea

Answer

Headache

Question 17

Which of the following medications is administered in the form of a prodrug?

Accepted Answer

Omeprazole

Answer

Ranitidine

Answer

Sucralfate

Answer

Misoprostol

Question 18

Which of the following drug interactions is NOT associated with the use of proton pump inhibitors?

Accepted Answer

Increased bioavailability of digoxin

Answer

Decreased iron absorption

Answer

Increased absorption of ketoconazole

Answer

Altered clearance of warfarin

Question 19

Which of the following medications is specifically indicated for the treatment of Zollinger-Ellison syndrome?

Accepted Answer

Omeprazole

Answer

Ranitidine

Answer

Sucralfate

Answer

Bismuth

Question 20

Which antiulcer drug class is most potent in inhibiting gastric acid secretion?

Accepted Answer

Proton pump inhibitors

Answer

H2-receptor antagonists

Answer

Antacids

Question 21

Describe the mechanism of action of proton pump inhibitors.

Accepted Answer

Irreversible inhibition of the H+/K+ ATPase pump

Answer

Neutralization of gastric acid

Answer

Formation of a protective barrier over the gastric mucosa

Answer

Competitive inhibition of histamine receptors

Question 22

Which of the following adverse effects is associated with proton pump inhibitors?

Accepted Answer

Vitamin B12 malabsorption

Answer

Hypotension

Answer

Tachycardia

Answer

Sedation

Question 23

What is the primary function of sucralfate in ulcer therapy?

Accepted Answer

Forms a protective barrier over the ulcer surface

Answer

Increases mucosal blood flow

Answer

Inhibits gastric acid secretion

Answer

Stimulates prostaglandin synthesis

Question 24

Which drug class is the preferred treatment for Zollinger-Ellison syndrome?

Accepted Answer

Proton pump inhibitors

Answer

Sucralfate

Answer

Antacids

Answer

H2-receptor antagonists

Question 25

Which of the following is NOT a therapeutic indication for antiulcer drugs?

Accepted Answer

Treatment of asthma

Answer

Prevention of stress ulcers

Answer

Treatment of peptic ulcers

Question 26

What pharmacological class refers to drugs that inhibit gastric acid secretion by blocking muscarinic cholinoreceptors?

Accepted Answer

Anticholinergics

Answer

H2-receptor antagonists

Answer

Proton pump inhibitors

Question 27

Which of the following antiulcer drugs is a prodrug that requires activation by gastric acid?

Accepted Answer

Omeprazole

Answer

Famotidine

Answer

Ranitidine

Answer

Sucralfate

Question 28

What is the main advantage of administering H2-receptor antagonists intravenously compared to proton pump inhibitors?

Accepted Answer

Faster onset of action

Answer

Fewer drug interactions

Answer

Lower cost

Answer

Longer duration of action