Master Pharmaceutical Manufacturing Processes: Unit Operations Quiz

Question 1

In pharmaceutical manufacturing, which factor does NOT significantly impact the effectiveness of a mixing process?

Accepted Answer

Temperature and humidity

Answer

Particle size and shape

Answer

Mixing duration

Answer

Impeller design and speed

Question 2

In pharmaceutical manufacturing, which technique is NOT employed to improve powder flowability through granulation?

Accepted Answer

Direct compression

Answer

Wet granulation

Answer

Dry granulation

Answer

Fluidized bed granulation

Question 3

In an experiment, impeller speed was found to have a linear relationship with mixing efficiency. Which of the following best explains this observation?

Accepted Answer

Impeller speed directly affects shear forces, influencing particle dispersion and mixing efficiency.

Answer

Impeller speed increases temperature, enhancing solubility and mixing.

Answer

Impeller speed reduces viscosity, facilitating particle movement and mixing.

Answer

Impeller speed has no impact on mixing efficiency; the linear relationship is coincidental.

Question 4

Which of the following is NOT considered a critical process parameter in mixing operations for pharmaceutical products?

Accepted Answer

Container volume

Answer

Impeller design and speed

Answer

Mixing time

Answer

Particle size distribution

Question 5

What is the primary objective of granulation in pharmaceutical manufacturing?

Accepted Answer

To improve flowability and compressibility of powders

Answer

To reduce electrostatic charge

Answer

To increase particle size

Answer

To enhance drug dissolution

Question 6

Which type of tablet press is most commonly used for high-speed production of pharmaceutical tablets?

Accepted Answer

Rotary tablet press

Answer

Single-station press

Answer

Semi-automatic press

Answer

Fully automatic press

Question 7

What is the purpose of milling in pharmaceutical operations?

Accepted Answer

To reduce particle size

Answer

To improve solubility

Answer

To enhance absorption

Answer

To increase bioavailability

Question 8

What is the primary advantage of freeze-drying over conventional drying methods for pharmaceutical products?

Accepted Answer

Preservation of product structure and stability

Answer

Reduced drying time

Answer

Lower energy consumption

Answer

Improved drug release

Question 9

Which of the following is NOT a technique used for particle size reduction in pharmaceutical manufacturing?

Accepted Answer

Wet granulation

Answer

Mechanical milling

Answer

Ultrasound

Answer

Cryogenic grinding

Question 10

What is the primary goal of filtration in pharmaceutical manufacturing?

Accepted Answer

To separate solids from liquids

Answer

To purify liquids

Answer

To remove gases from liquids

Answer

To concentrate solutions

Question 11

Which of these is NOT a common piece of equipment used for mixing in pharmaceutical manufacturing?

Accepted Answer

Extruder

Answer

Ribbon blender

Answer

V-blender

Answer

Planetary mixer

Question 12

In pharmaceutical manufacturing, is process validation considered a mandatory requirement or an optional practice?

Accepted Answer

Mandatory requirement

Answer

Optional practice

Question 13

Which type of granulation involves the formation of granules using a binder solution heated above its melting point?

Accepted Answer

Melt granulation

Answer

Dry granulation

Answer

Wet granulation

Answer

Fluidized bed granulation

Question 14

What is the primary mechanism responsible for the transformation of powder particles into a cohesive mass during tableting?

Accepted Answer

Plastic deformation

Answer

Elastic deformation

Answer

Shear deformation

Question 15

What is the primary purpose of adding a lubricant to a tablet formulation?

Accepted Answer

To reduce friction between tablet components and tooling during compression

Answer

To improve the flowability of the powder blend

Answer

To enhance bonding properties of the granules

Question 16

What is the primary function of a hopper in a tablet press?

Accepted Answer

To store and feed the powder blend into the die cavity

Answer

To pre-compress the powder blend

Answer

To lubricate the tablet surface

Answer

To transfer the powder blend into the die cavity

Question 17

What is the main objective of the compression step in tableting?

Accepted Answer

To consolidate and compact the powder blend into a solid dosage form

Answer

To reduce tablet friability

Answer

To improve the bioavailability of the drug

Question 18

Which of the following is NOT a type of tablet coating?

Accepted Answer

Compression coating

Answer

Sugar coating

Answer

Enteric coating

Answer

Film coating

Question 19

Which type of granulator is best suited for producing granules with high porosity and uniform size distribution?

Accepted Answer

Fluidized bed granulator

Answer

High-shear mixer granulator

Answer

Roller compactor

Answer

Double cone blender

Question 20

What is the primary purpose of tableting in pharmaceutical manufacturing?

Accepted Answer

To convert powders or granules into solid dosage forms

Answer

To reduce the size of particles

Answer

To improve taste and appearance

Answer

To enhance drug absorption

Question 21

What is the purpose of a deduster in a tableting process?

Accepted Answer

To remove excess powder from tablets, reducing the risk of sticking and defects

Answer

To control tablet weight

Answer

To lubricate tablets

Answer

To polish tablets

Question 22

Which of the following is a common method used to coat tablets?

Accepted Answer

Film coating

Answer

Compression

Answer

Extrusion

Answer

Encapsulation

Question 23

What is the primary purpose of using a granulation binder?

Accepted Answer

To bind particles together and form stable granules

Answer

To enhance the dissolution rate of the granules

Answer

To improve the flowability of the granules

Answer

To reduce the moisture content of the granules