Dosage Form Design Quizzes: Master Pharmaceutics Concepts

Question 1

In tablet formulations, which excipient is commonly utilized to enhance flowability?

Accepted Answer

Magnesium stearate

Answer

Lactose

Answer

Starch

Answer

Talc

Question 2

What is the primary objective of a sustained-release dosage form?

Accepted Answer

Reduced dosing frequency

Answer

Increased drug bioavailability

Answer

Improved patient compliance

Answer

Targeted delivery to specific organs

Question 3

During the development of parenteral dosage forms, which of the following presents a significant challenge?

Accepted Answer

Maintaining sterility

Answer

Managing pain during injection

Answer

Limited drug loading capacity

Answer

High manufacturing cost

Question 4

What is the main purpose of conducting a bioavailability study?

Accepted Answer

Determining the rate and extent of drug absorption

Answer

Evaluating the efficacy of a new drug

Answer

Assessing the safety and toxicity of a drug

Answer

Comparing different dosage forms of a drug

Question 5

Which of the following is an example of a dosage form designed for controlled drug release?

Accepted Answer

Transdermal patch

Answer

Immediate-release tablet

Answer

Intravenous injection

Answer

Suppository

Question 6

How does the Biopharmaceutics Classification System (BCS) inform the choice of dosage forms?

Accepted Answer

BCS classifies drugs based on solubility and permeability, guiding dosage form design to enhance drug absorption.

Answer

BCS is the only factor considered when selecting a dosage form for a drug.

Answer

BCS is only applicable to solid oral dosage forms.

Answer

BCS does not provide information on drug bioavailability.

Question 7

Which of the following is a fundamental principle of Quality by Design (QbD) in dosage form development?

Accepted Answer

Encompassing the entire product lifecycle from design to manufacturing

Answer

Prioritizing cost-effectiveness over product quality

Answer

Relying on trial and error rather than scientific understanding

Question 8

Which factor is NOT considered when selecting an appropriate dosage form?

Accepted Answer

Availability of the drug in the desired dosage strength

Answer

Patient's age and physiological status

Answer

Route of administration

Answer

Drug stability and solubility

Question 9

For a poorly water-soluble drug, which dosage form is most suitable to achieve rapid drug release?

Accepted Answer

Solution

Answer

Tablet

Answer

Capsule

Answer

Sustained-release tablet

Question 10

Which excipient is commonly employed as a binder in solid oral dosage forms?

Accepted Answer

Starch

Answer

Alcohol

Answer

Water

Answer

Oil

Question 11

What is the primary mechanism by which drugs are released from a suppository?

Accepted Answer

Diffusion

Answer

Dissolution

Answer

Erosion

Answer

Osmosis

Question 12

Which of the following is NOT a type of transdermal drug delivery system?

Accepted Answer

Suppository

Answer

Patch

Answer

Ointment

Answer

Gel

Question 13

Which dosage form would be most suitable for delivering a drug that is rapidly absorbed from the gastrointestinal tract and requires frequent dosing?

Accepted Answer

Oral solution

Answer

Sustained-release tablet

Answer

Transdermal patch

Answer

Suppository

Question 14

What is the key difference between a tablet and a capsule?

Accepted Answer

Tablets are compressed, while capsules are filled

Answer

Tablets disintegrate more rapidly than capsules

Answer

Capsules are more stable than tablets

Answer

Tablets have a larger drug loading capacity than capsules

Question 15

Which of the following is **NOT** a primary factor considered during dosage form design?

Accepted Answer

Cost of manufacturing

Answer

Patient compliance

Answer

Route of administration

Answer

Dosage regimen

Question 16

Which of the following is a significant challenge associated with the formulation of **parenteral** dosage forms?

Accepted Answer

Ensuring sterility

Answer

Maintaining stability

Answer

Achieving desired release rate

Answer

Overcoming first-pass metabolism

Question 17

What is the primary rationale for using a **suppository** dosage form?

Accepted Answer

Local or systemic delivery to the rectum

Answer

Avoidance of first-pass metabolism

Answer

Improved patient comfort

Answer

Rapid onset of action

Question 18

What is the primary purpose of using a **controlled-release** mechanism in a dosage form?

Accepted Answer

To maintain therapeutic drug levels over an extended period

Answer

To enhance absorption

Answer

To reduce side effects

Question 19

What is the **primary** goal of **optimizing** a dosage form?

Accepted Answer

To ensure optimal therapeutic efficacy and safety

Answer

To improve patient convenience

Answer

To reduce manufacturing costs

Question 20

A pharmaceutical company is developing a new drug for the treatment of chronic obstructive pulmonary disease (COPD). The drug is rapidly metabolized in the liver. Which dosage form would be MOST suitable for this drug, considering its rapid hepatic metabolism?

Accepted Answer

Dry powder inhaler

Answer

Intravenous injection

Answer

Oral tablet

Answer

Subcutaneous implant

Question 21

Which of the following is NOT a factor to consider when selecting a dosage form for a pediatric patient?

Accepted Answer

Patient's income level

Answer

Swallowing ability and taste preferences

Answer

Required dose and frequency of administration

Answer

Child's age and developmental stage

Question 22

What is the PRIMARY advantage of developing a drug as a sustained-release tablet?

Accepted Answer

Improved patient compliance

Answer

Faster onset of action

Answer

Reduced manufacturing cost

Answer

Elimination of side effects

Question 23

Which excipient is added to a tablet formulation to improve its flow properties during the manufacturing process?

Accepted Answer

Glidant

Answer

Binder

Answer

Lubricant

Answer

Disintegrant

Question 24

Which dosage form is designed to deliver a drug through the skin for systemic absorption?

Accepted Answer

Transdermal patch

Answer

Gel

Answer

Ointment

Answer

Cream

Question 25

What is the purpose of conducting a dissolution test on a tablet formulation?

Accepted Answer

To assess the rate and extent of drug release from the dosage form

Answer

To evaluate the drug's stability in the formulation

Answer

To determine the tablet's hardness and friability

Question 26

Which route of administration is generally associated with the highest bioavailability?

Accepted Answer

Intravenous

Answer

Oral

Answer

Subcutaneous

Answer

Intramuscular

Question 27

Which of the following is an advantage of using nanoparticles in drug delivery?

Accepted Answer

Improved drug solubility and dissolution rate

Answer

Larger required dose

Answer

Reduced manufacturing complexity

Answer

Increased drug toxicity

Question 28

A drug exhibits extensive first-pass metabolism. How might this influence the design of its dosage form?

Accepted Answer

Consider alternative routes of administration or formulation strategies to bypass first-pass metabolism

Answer

The drug can be formulated as a conventional oral tablet without any modifications

Question 29

What is the primary function of a preservative in a liquid dosage form?

Accepted Answer

To prevent microbial growth

Answer

To improve product aesthetics

Answer

To enhance drug solubility

Answer

To mask unpleasant taste