Drugs Used in Peptic Ulcer Disease: Online Quizzes and Learning

Question 1

Which drug is a competitive antagonist of histamine at H2-receptors?

Accepted Answer

Cimetidine

Answer

Omeprazole

Answer

Sucralfate

Answer

Misoprostol

Question 2

Sucralfate is classified as a:

Accepted Answer

Cytoprotective agent

Answer

Proton pump inhibitor

Answer

H2-receptor antagonist

Answer

Antacid

Question 3

In managing peptic ulcer disease, how crucial are lifestyle modifications?

Accepted Answer

Essential

Answer

Somewhat significant

Answer

Insignificant

Answer

Potentially harmful

Question 4

How do proton pump inhibitors and H2-receptor antagonists differ in their mechanisms of action to inhibit gastric acid secretion?

Accepted Answer

Proton pump inhibitors irreversibly bind to H+, K+-ATPase, while H2-receptor antagonists reversibly inhibit histamine binding.

Answer

Proton pump inhibitors reversibly inhibit histamine binding, while H2-receptor antagonists irreversibly block H+, K+-ATPase.

Answer

Both proton pump inhibitors and H2-receptor antagonists reversibly inhibit H+, K+-ATPase.

Answer

Both proton pump inhibitors and H2-receptor antagonists irreversibly block histamine binding.

Question 5

Which of the following is a proton pump inhibitor (PPI)?

Accepted Answer

Omeprazole

Answer

Cimetidine

Answer

Sucralfate

Answer

Magnesium hydroxide

Question 6

Which of the following is a key mechanism of action of proton pump inhibitors (PPIs)?

Accepted Answer

Inhibition of H+/K+-ATPase in the gastric parietal cells, reducing acid secretion

Answer

Increase in gastric mucus production

Answer

Neutralization of gastric acid

Answer

Stimulation of prostaglandin synthesis

Question 7

Which of the following adverse effects is commonly associated with the use of antacids?

Accepted Answer

Constipation

Answer

Headache

Answer

Dizziness

Answer

Blurred vision

Question 8

Which of the following drugs is contraindicated in patients with impaired kidney function?

Accepted Answer

Edoxaban

Answer

Omeprazole

Answer

Ranitidine

Answer

Sucralfate

Question 9

Which type of peptic ulcer is the most prevalent?

Accepted Answer

Duodenal ulcer

Answer

Gastric ulcer

Answer

Esophageal ulcer

Answer

Stress ulcer

Question 10

Which of the following is NOT a risk factor for peptic ulcer disease?

Accepted Answer

Healthy diet

Answer

Helicobacter pylori infection

Answer

Non-steroidal anti-inflammatory drug (NSAID) use

Answer

Smoking

Question 11

What is the primary function of proton pump inhibitors?

Accepted Answer

Block gastric acid secretion

Answer

Increase mucus production

Answer

Neutralize gastric acid

Answer

Inhibit pepsin activity

Question 12

How do proton pump inhibitors (PPIs) primarily work to treat peptic ulcer disease?

Accepted Answer

By irreversibly blocking the gastric H+,K+-ATPase enzyme, reducing acid secretion

Answer

By neutralizing gastric acid and forming a protective layer on the gastric mucosa

Answer

By stimulating gastric mucus secretion to protect the gastric mucosa

Question 13

How do proton pump inhibitors primarily exert their therapeutic effect?

Accepted Answer

By irreversibly inhibiting the H+/K+ ATPase enzyme in gastric parietal cells

Answer

By competitively inhibiting histamine receptors on parietal cells

Answer

By neutralizing acid within the gastric lumen

Question 14

In a patient with frequent heartburn and dyspepsia, the initial treatment for presumed peptic ulcer disease should be:

Accepted Answer

A proton pump inhibitor (PPI)

Answer

An H2-receptor antagonist

Answer

A sucralfate

Answer

An antacid

Question 15

Which mode of action is common to both proton pump inhibitors (PPIs) and H2-receptor antagonists?

Accepted Answer

Reducing gastric acid secretion

Answer

Neutralizing gastric acid

Answer

Increasing gastric mucosal bicarbonate secretion

Answer

Protecting the gastric mucosa

Question 16

Long-term use of proton pump inhibitors (PPIs) has been associated with increased risk of:

Accepted Answer

Osteoporosis

Answer

Diarrhea

Answer

Hepatotoxicity

Answer

Hypersensitivity reactions

Question 17

For rapid relief of pain in peptic ulcer disease, the most suitable option is:

Accepted Answer

An antacid

Answer

A misoprostol

Answer

An H2-receptor antagonist

Answer

A sucralfate

Question 18

In patients taking long-term nonsteroidal anti-inflammatory drugs (NSAIDs), the most effective medication to prevent peptic ulcer disease is:

Accepted Answer

Misoprostol

Answer

Sucralfate

Answer

Ranitidine

Answer

Omeprazole

Question 19

In patients with Helicobacter pylori infection and peptic ulcer disease, the standard drug combination for eradication of H. pylori is:

Accepted Answer

Amoxicillin + Clarithromycin + Omeprazole

Answer

Metronidazole + Tetracycline + Ranitidine

Answer

Amoxicillin + Metronidazole + Lansoprazole

Answer

Bismuth subsalicylate + Clarithromycin + Lansoprazole

Question 20

The mechanism of action of sucralfate is to:

Accepted Answer

Form a protective barrier over the ulcerated mucosa

Answer

Directly inhibit gastric acid secretion

Answer

Neutralize gastric acid

Question 21

When selecting a proton pump inhibitor (PPI) for a patient, important factors to consider include:

Accepted Answer

Patient's age and renal function

Answer

Patient's preference for a particular brand name

Answer

Cost of the medication

Answer

Availability of the medication in different dosage forms

Question 22

Regarding the use of antacids in peptic ulcer disease management:

Accepted Answer

Antacids provide rapid symptom relief but have limited long-term efficacy.

Answer

Antacids are the most effective drugs for the treatment of peptic ulcer disease.

Answer

Antacids are contraindicated in patients with renal insufficiency.

Question 23

A patient with peptic ulcer disease should be advised that smoking and alcohol consumption

Accepted Answer

Impair ulcer healing

Answer

Have no effect on ulcer healing

Answer

Promote ulcer healing